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Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice
OBJECTIVE: To investigate the anticonvulsant and muscle relxant activity of ethanolic extract of stems of Dendrophthoe falcata in mice. MATERIALS AND METHODS: The ethanolic extract of stems of D. falcata (100, 300 and 500 mg/kg, p.o.) was studied for its anticonvulsant effect on maximal electroshock...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229791/ https://www.ncbi.nlm.nih.gov/pubmed/22144780 http://dx.doi.org/10.4103/0253-7613.89832 |
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author | Sinoriya, Pooja Irchhaiya, R. Sharma, Bhawna Sahu, Gayatri Kumar, Santosh |
author_facet | Sinoriya, Pooja Irchhaiya, R. Sharma, Bhawna Sahu, Gayatri Kumar, Santosh |
author_sort | Sinoriya, Pooja |
collection | PubMed |
description | OBJECTIVE: To investigate the anticonvulsant and muscle relxant activity of ethanolic extract of stems of Dendrophthoe falcata in mice. MATERIALS AND METHODS: The ethanolic extract of stems of D. falcata (100, 300 and 500 mg/kg, p.o.) was studied for its anticonvulsant effect on maximal electroshock-induced seizures and muscle relaxant activity at the same dose level using rota rod and traction test in mice. RESULTS: Preliminary phytochemical analysis revealed presence of proteins, carbohydrates, glycosides, steroids, triterpenes, flavonoids, tannins and phenolic compounds. D. falcata ethanolic extract (DFEE) (100, 300 and 500 mg/kg, p.o.) significantly (P<0.001) inhibited seizures induced by MES, reduced the duration of Hind limb tonic extensor phase (HLTE) and a decline in motor coordination. CONCLUSION: The ethanolic extract possesses anticonvulsant activity and muscle relaxant activity. |
format | Online Article Text |
id | pubmed-3229791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-32297912011-12-05 Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice Sinoriya, Pooja Irchhaiya, R. Sharma, Bhawna Sahu, Gayatri Kumar, Santosh Indian J Pharmacol Short Communication OBJECTIVE: To investigate the anticonvulsant and muscle relxant activity of ethanolic extract of stems of Dendrophthoe falcata in mice. MATERIALS AND METHODS: The ethanolic extract of stems of D. falcata (100, 300 and 500 mg/kg, p.o.) was studied for its anticonvulsant effect on maximal electroshock-induced seizures and muscle relaxant activity at the same dose level using rota rod and traction test in mice. RESULTS: Preliminary phytochemical analysis revealed presence of proteins, carbohydrates, glycosides, steroids, triterpenes, flavonoids, tannins and phenolic compounds. D. falcata ethanolic extract (DFEE) (100, 300 and 500 mg/kg, p.o.) significantly (P<0.001) inhibited seizures induced by MES, reduced the duration of Hind limb tonic extensor phase (HLTE) and a decline in motor coordination. CONCLUSION: The ethanolic extract possesses anticonvulsant activity and muscle relaxant activity. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3229791/ /pubmed/22144780 http://dx.doi.org/10.4103/0253-7613.89832 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Sinoriya, Pooja Irchhaiya, R. Sharma, Bhawna Sahu, Gayatri Kumar, Santosh Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice |
title | Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice |
title_full | Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice |
title_fullStr | Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice |
title_full_unstemmed | Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice |
title_short | Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice |
title_sort | anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of dendrophthoe falcata (linn. f.) in mice |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229791/ https://www.ncbi.nlm.nih.gov/pubmed/22144780 http://dx.doi.org/10.4103/0253-7613.89832 |
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