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Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice

OBJECTIVE: To investigate the anticonvulsant and muscle relxant activity of ethanolic extract of stems of Dendrophthoe falcata in mice. MATERIALS AND METHODS: The ethanolic extract of stems of D. falcata (100, 300 and 500 mg/kg, p.o.) was studied for its anticonvulsant effect on maximal electroshock...

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Autores principales: Sinoriya, Pooja, Irchhaiya, R., Sharma, Bhawna, Sahu, Gayatri, Kumar, Santosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229791/
https://www.ncbi.nlm.nih.gov/pubmed/22144780
http://dx.doi.org/10.4103/0253-7613.89832
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author Sinoriya, Pooja
Irchhaiya, R.
Sharma, Bhawna
Sahu, Gayatri
Kumar, Santosh
author_facet Sinoriya, Pooja
Irchhaiya, R.
Sharma, Bhawna
Sahu, Gayatri
Kumar, Santosh
author_sort Sinoriya, Pooja
collection PubMed
description OBJECTIVE: To investigate the anticonvulsant and muscle relxant activity of ethanolic extract of stems of Dendrophthoe falcata in mice. MATERIALS AND METHODS: The ethanolic extract of stems of D. falcata (100, 300 and 500 mg/kg, p.o.) was studied for its anticonvulsant effect on maximal electroshock-induced seizures and muscle relaxant activity at the same dose level using rota rod and traction test in mice. RESULTS: Preliminary phytochemical analysis revealed presence of proteins, carbohydrates, glycosides, steroids, triterpenes, flavonoids, tannins and phenolic compounds. D. falcata ethanolic extract (DFEE) (100, 300 and 500 mg/kg, p.o.) significantly (P<0.001) inhibited seizures induced by MES, reduced the duration of Hind limb tonic extensor phase (HLTE) and a decline in motor coordination. CONCLUSION: The ethanolic extract possesses anticonvulsant activity and muscle relaxant activity.
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spelling pubmed-32297912011-12-05 Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice Sinoriya, Pooja Irchhaiya, R. Sharma, Bhawna Sahu, Gayatri Kumar, Santosh Indian J Pharmacol Short Communication OBJECTIVE: To investigate the anticonvulsant and muscle relxant activity of ethanolic extract of stems of Dendrophthoe falcata in mice. MATERIALS AND METHODS: The ethanolic extract of stems of D. falcata (100, 300 and 500 mg/kg, p.o.) was studied for its anticonvulsant effect on maximal electroshock-induced seizures and muscle relaxant activity at the same dose level using rota rod and traction test in mice. RESULTS: Preliminary phytochemical analysis revealed presence of proteins, carbohydrates, glycosides, steroids, triterpenes, flavonoids, tannins and phenolic compounds. D. falcata ethanolic extract (DFEE) (100, 300 and 500 mg/kg, p.o.) significantly (P<0.001) inhibited seizures induced by MES, reduced the duration of Hind limb tonic extensor phase (HLTE) and a decline in motor coordination. CONCLUSION: The ethanolic extract possesses anticonvulsant activity and muscle relaxant activity. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3229791/ /pubmed/22144780 http://dx.doi.org/10.4103/0253-7613.89832 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Sinoriya, Pooja
Irchhaiya, R.
Sharma, Bhawna
Sahu, Gayatri
Kumar, Santosh
Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice
title Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice
title_full Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice
title_fullStr Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice
title_full_unstemmed Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice
title_short Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice
title_sort anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of dendrophthoe falcata (linn. f.) in mice
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229791/
https://www.ncbi.nlm.nih.gov/pubmed/22144780
http://dx.doi.org/10.4103/0253-7613.89832
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