Phenytoin induced chorea in a pediatric patient: An interaction between phenytoin, phenobarbital and clobazam

A 3-year-old female patient developed chorea possibly due to an interaction between phenytoin, phenobarbital and clobazam used for generalized tonic clonic seizures. Phenytoin withdrawal resulted in recovery within 24 hours. Post reaction computerized tomography (CT)-scan of brain was normal. Combin...

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Detalles Bibliográficos
Autores principales: Barvaliya, Manish, Sanmukhani, Jayesh, Patel, Tejas K., Tripathi, C.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Drug Watch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229798/
https://www.ncbi.nlm.nih.gov/pubmed/22144787
http://dx.doi.org/10.4103/0253-7613.89839
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author Barvaliya, Manish
Sanmukhani, Jayesh
Patel, Tejas K.
Tripathi, C.B.
author_facet Barvaliya, Manish
Sanmukhani, Jayesh
Patel, Tejas K.
Tripathi, C.B.
author_sort Barvaliya, Manish
collection PubMed
description A 3-year-old female patient developed chorea possibly due to an interaction between phenytoin, phenobarbital and clobazam used for generalized tonic clonic seizures. Phenytoin withdrawal resulted in recovery within 24 hours. Post reaction computerized tomography (CT)-scan of brain was normal. Combined use of anti-seizure drugs and interactions between them may be responsible for the reaction. Therapeutic drug monitoring is important while prescribing two or more anti-seizure drugs.
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spelling pubmed-32297982011-12-05 Phenytoin induced chorea in a pediatric patient: An interaction between phenytoin, phenobarbital and clobazam Barvaliya, Manish Sanmukhani, Jayesh Patel, Tejas K. Tripathi, C.B. Indian J Pharmacol Drug Watch A 3-year-old female patient developed chorea possibly due to an interaction between phenytoin, phenobarbital and clobazam used for generalized tonic clonic seizures. Phenytoin withdrawal resulted in recovery within 24 hours. Post reaction computerized tomography (CT)-scan of brain was normal. Combined use of anti-seizure drugs and interactions between them may be responsible for the reaction. Therapeutic drug monitoring is important while prescribing two or more anti-seizure drugs. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3229798/ /pubmed/22144787 http://dx.doi.org/10.4103/0253-7613.89839 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Drug Watch
Barvaliya, Manish
Sanmukhani, Jayesh
Patel, Tejas K.
Tripathi, C.B.
Phenytoin induced chorea in a pediatric patient: An interaction between phenytoin, phenobarbital and clobazam
title Phenytoin induced chorea in a pediatric patient: An interaction between phenytoin, phenobarbital and clobazam
title_full Phenytoin induced chorea in a pediatric patient: An interaction between phenytoin, phenobarbital and clobazam
title_fullStr Phenytoin induced chorea in a pediatric patient: An interaction between phenytoin, phenobarbital and clobazam
title_full_unstemmed Phenytoin induced chorea in a pediatric patient: An interaction between phenytoin, phenobarbital and clobazam
title_short Phenytoin induced chorea in a pediatric patient: An interaction between phenytoin, phenobarbital and clobazam
title_sort phenytoin induced chorea in a pediatric patient: an interaction between phenytoin, phenobarbital and clobazam
topic Drug Watch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229798/
https://www.ncbi.nlm.nih.gov/pubmed/22144787
http://dx.doi.org/10.4103/0253-7613.89839
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