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Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling

We have shown before that constitutive DNA damage signaling represented by H2AX-Ser139 phosphorylation and ATM activation in untreated normal and tumor cells is a reporter of the persistent DNA replication stress induced by endogenous oxidants, the by-products of aerobic respiration. In the present...

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Detalles Bibliográficos
Autores principales:	Halicka, H. Dorota, Zhao, Hong, Li, Jiangwei, Traganos, Frank, Zhang, Sufang, Lee, Marietta, Darzynkiewicz, Zbigniew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2011
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229966/ https://www.ncbi.nlm.nih.gov/pubmed/22067284

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