Characterization of spontaneously generated prion-like conformers in cultured cells

A distinct conformational transition from the α-helix-rich cellular prion protein (PrP(C)) into its β-sheet-rich pathological isoform (PrP(Sc)) is the hallmark of prion diseases, a group of fatal transmissible encephalopathies that includes spontaneous and acquired forms. Recently, a PrP(Sc)-like in...

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Detalles Bibliográficos
Autores principales: Zou, Roger S., Fujioka, Hisashi, Guo, Jian-Ping, Xiao, Xiangzhu, Shimoji, Miyuki, Kong, Crystal, Chen, Cecilia, Tasnadi, Megan, Voma, Chesinta, Yuan, Jue, Moudjou, Mohammed, Laude, Hubert, Petersen, Robert B., Zou, Wen-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229973/
https://www.ncbi.nlm.nih.gov/pubmed/21990137

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