Cargando…

Lipids, curvature, and nano-medicine*

The physical properties of the lamellar lipid-bilayer component of biological membranes are controlled by a host of thermodynamic forces leading to overall tensionless bilayers with a conspicuous lateral pressure profile and build-in curvature-stress instabilities that may be released locally or glo...

Descripción completa

Detalles Bibliográficos
Autor principal: Mouritsen, Ole G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229985/
https://www.ncbi.nlm.nih.gov/pubmed/22164124
http://dx.doi.org/10.1002/ejlt.201100050
_version_ 1782218016081051648
author Mouritsen, Ole G
author_facet Mouritsen, Ole G
author_sort Mouritsen, Ole G
collection PubMed
description The physical properties of the lamellar lipid-bilayer component of biological membranes are controlled by a host of thermodynamic forces leading to overall tensionless bilayers with a conspicuous lateral pressure profile and build-in curvature-stress instabilities that may be released locally or globally in terms of morphological changes. In particular, the average molecular shape and the propensity of the different lipid and protein species for forming non-lamellar and curved structures are a source of structural transitions and control of biological function. The effects of different lipids, sterols, and proteins on membrane structure are discussed and it is shown how one can take advantage of the curvature-stress modulations brought about by specific molecular agents, such as fatty acids, lysolipids, and other amphiphilic solutes, to construct intelligent drug-delivery systems that function by enzymatic triggering via curvature. Practical applications: The simple concept of lipid molecular shape and how it impacts on the structure of lipid aggregates, in particular the curvature and curvature stress in lipid bilayers and liposomes, can be exploited to construct liposome-based drug-delivery systems, e.g., for use as nano-medicine in cancer therapy. Non-lamellar-forming lysolipids and fatty acids, some of which may be designed to be prodrugs, can be created by phospholipase action in diseased tissues thereby providing for targeted drug release and proliferation of molecular entities with conical shape that break down the permeability barrier of the target cells and may hence enhance efficacy.
format Online
Article
Text
id pubmed-3229985
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher WILEY-VCH Verlag
record_format MEDLINE/PubMed
spelling pubmed-32299852011-12-05 Lipids, curvature, and nano-medicine* Mouritsen, Ole G Eur J Lipid Sci Technol Highlight Article The physical properties of the lamellar lipid-bilayer component of biological membranes are controlled by a host of thermodynamic forces leading to overall tensionless bilayers with a conspicuous lateral pressure profile and build-in curvature-stress instabilities that may be released locally or globally in terms of morphological changes. In particular, the average molecular shape and the propensity of the different lipid and protein species for forming non-lamellar and curved structures are a source of structural transitions and control of biological function. The effects of different lipids, sterols, and proteins on membrane structure are discussed and it is shown how one can take advantage of the curvature-stress modulations brought about by specific molecular agents, such as fatty acids, lysolipids, and other amphiphilic solutes, to construct intelligent drug-delivery systems that function by enzymatic triggering via curvature. Practical applications: The simple concept of lipid molecular shape and how it impacts on the structure of lipid aggregates, in particular the curvature and curvature stress in lipid bilayers and liposomes, can be exploited to construct liposome-based drug-delivery systems, e.g., for use as nano-medicine in cancer therapy. Non-lamellar-forming lysolipids and fatty acids, some of which may be designed to be prodrugs, can be created by phospholipase action in diseased tissues thereby providing for targeted drug release and proliferation of molecular entities with conical shape that break down the permeability barrier of the target cells and may hence enhance efficacy. WILEY-VCH Verlag 2011-10 /pmc/articles/PMC3229985/ /pubmed/22164124 http://dx.doi.org/10.1002/ejlt.201100050 Text en Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Highlight Article
Mouritsen, Ole G
Lipids, curvature, and nano-medicine*
title Lipids, curvature, and nano-medicine*
title_full Lipids, curvature, and nano-medicine*
title_fullStr Lipids, curvature, and nano-medicine*
title_full_unstemmed Lipids, curvature, and nano-medicine*
title_short Lipids, curvature, and nano-medicine*
title_sort lipids, curvature, and nano-medicine*
topic Highlight Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229985/
https://www.ncbi.nlm.nih.gov/pubmed/22164124
http://dx.doi.org/10.1002/ejlt.201100050
work_keys_str_mv AT mouritsenoleg lipidscurvatureandnanomedicine