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Little Impact of Antiplatelet Agents on Venous Thromboembolism after Hip Fracture Surgery

Since the late 1980s, low dose aspirin has been used to prevent stroke and ischemic heart disease. However, prophylactic effect of antiplatelets against venous thromboembolism (VTE), in patients who undergo hip fracture surgery (HFS) is controversial. Our purpose was to determine the incidence of sy...

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Autores principales: Ji, Hyung-Min, Lee, Young-Kyun, Ha, Yong-Chan, Kim, Ki-Choul, Koo, Kyung-Hoi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230024/
https://www.ncbi.nlm.nih.gov/pubmed/22148001
http://dx.doi.org/10.3346/jkms.2011.26.12.1625
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author Ji, Hyung-Min
Lee, Young-Kyun
Ha, Yong-Chan
Kim, Ki-Choul
Koo, Kyung-Hoi
author_facet Ji, Hyung-Min
Lee, Young-Kyun
Ha, Yong-Chan
Kim, Ki-Choul
Koo, Kyung-Hoi
author_sort Ji, Hyung-Min
collection PubMed
description Since the late 1980s, low dose aspirin has been used to prevent stroke and ischemic heart disease. However, prophylactic effect of antiplatelets against venous thromboembolism (VTE), in patients who undergo hip fracture surgery (HFS) is controversial. Our purpose was to determine the incidence of symptomatic VTE after HFS and to evaluate whether antiplatelets reduce the development of symptomatic VTE following HFS. We retrospectively reviewed 858 HFS in 824 consecutive patients which were performed from May 2003 to April 2010 at an East Asian institute. We compared the incidence of symptomatic VTE in antiplatelet users and non-users using multivariate logistic regression analyses. Overall incidences of symptomatic pulmonary embolism including fatal pulmonary embolism, and symptomatic deep vein thrombosis in this study were 2.4% (21/858), and 3.5% (30/858), respectively. The incidence of symptomatic VTE was 4.8% (12/250) in antiplatelet users and 4.3% (26/608) in non-users (P = 0.718). It is suggested that antiplatelet agents are not effective in prevention of symptomatic VTE after HFS.
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spelling pubmed-32300242011-12-06 Little Impact of Antiplatelet Agents on Venous Thromboembolism after Hip Fracture Surgery Ji, Hyung-Min Lee, Young-Kyun Ha, Yong-Chan Kim, Ki-Choul Koo, Kyung-Hoi J Korean Med Sci Original Article Since the late 1980s, low dose aspirin has been used to prevent stroke and ischemic heart disease. However, prophylactic effect of antiplatelets against venous thromboembolism (VTE), in patients who undergo hip fracture surgery (HFS) is controversial. Our purpose was to determine the incidence of symptomatic VTE after HFS and to evaluate whether antiplatelets reduce the development of symptomatic VTE following HFS. We retrospectively reviewed 858 HFS in 824 consecutive patients which were performed from May 2003 to April 2010 at an East Asian institute. We compared the incidence of symptomatic VTE in antiplatelet users and non-users using multivariate logistic regression analyses. Overall incidences of symptomatic pulmonary embolism including fatal pulmonary embolism, and symptomatic deep vein thrombosis in this study were 2.4% (21/858), and 3.5% (30/858), respectively. The incidence of symptomatic VTE was 4.8% (12/250) in antiplatelet users and 4.3% (26/608) in non-users (P = 0.718). It is suggested that antiplatelet agents are not effective in prevention of symptomatic VTE after HFS. The Korean Academy of Medical Sciences 2011-12 2011-11-29 /pmc/articles/PMC3230024/ /pubmed/22148001 http://dx.doi.org/10.3346/jkms.2011.26.12.1625 Text en © 2011 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ji, Hyung-Min
Lee, Young-Kyun
Ha, Yong-Chan
Kim, Ki-Choul
Koo, Kyung-Hoi
Little Impact of Antiplatelet Agents on Venous Thromboembolism after Hip Fracture Surgery
title Little Impact of Antiplatelet Agents on Venous Thromboembolism after Hip Fracture Surgery
title_full Little Impact of Antiplatelet Agents on Venous Thromboembolism after Hip Fracture Surgery
title_fullStr Little Impact of Antiplatelet Agents on Venous Thromboembolism after Hip Fracture Surgery
title_full_unstemmed Little Impact of Antiplatelet Agents on Venous Thromboembolism after Hip Fracture Surgery
title_short Little Impact of Antiplatelet Agents on Venous Thromboembolism after Hip Fracture Surgery
title_sort little impact of antiplatelet agents on venous thromboembolism after hip fracture surgery
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230024/
https://www.ncbi.nlm.nih.gov/pubmed/22148001
http://dx.doi.org/10.3346/jkms.2011.26.12.1625
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