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Renin–angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study

BACKGROUND: Elevated renin–angiotensin–aldosterone system (RAAS) activity is an important mechanism in the development of hypertension. Both obesity and 25-hydroxy vitamin D [25(OH)D] deficiency have been associated with hypertension and augmented renin-angiotensin system (RAS) activity. We tried to...

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Autores principales: Kota, Sunil Kumar, Kota, Siva Krishna, Jammula, Sruti, Meher, Lalit Kumar, Panda, Sandip, Tripathy, Prabhas Rranjan, Modi, Kirtikumar D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230105/
https://www.ncbi.nlm.nih.gov/pubmed/22145146
http://dx.doi.org/10.4103/2230-8210.86985
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author Kota, Sunil Kumar
Kota, Siva Krishna
Jammula, Sruti
Meher, Lalit Kumar
Panda, Sandip
Tripathy, Prabhas Rranjan
Modi, Kirtikumar D.
author_facet Kota, Sunil Kumar
Kota, Siva Krishna
Jammula, Sruti
Meher, Lalit Kumar
Panda, Sandip
Tripathy, Prabhas Rranjan
Modi, Kirtikumar D.
author_sort Kota, Sunil Kumar
collection PubMed
description BACKGROUND: Elevated renin–angiotensin–aldosterone system (RAAS) activity is an important mechanism in the development of hypertension. Both obesity and 25-hydroxy vitamin D [25(OH)D] deficiency have been associated with hypertension and augmented renin-angiotensin system (RAS) activity. We tried to test the hypothesis that vitamin D deficiency and obesity are associated with increased RAS activity in Indian patients with hypertension. MATERIALS AND METHODS: Fifty newly detected hypertensive patients were screened. Patients with secondary hypertension, chronic kidney disease, or coronary artery disease were excluded. Patients underwent measurement of vitamin D and plasma renin and plasma aldosterone concentrations. They were divided into three groups according to their baseline body mass index (BMI; normal <25 kg/m(2), overweight 25–29.9 kg/m(2) and obese ≥30 kg/m(2)) and 25(OH)D levels (deficient <20 ng/ml, insufficient 20–29 ng/ml and optimal ≥30 ng/ml). RESULTS: A total of 50 (male:female – 32:18) patients were included, with a mean age of 49.5 ± 7.8 years, mean BMI of 28.3 ± 3.4 kg/m(2) and a mean 25(OH)D concentration of 18.5 ± 6.4 ng/ml. Mean systolic blood pressure (SBP) was 162.4 ± 20.2 mm Hg and mean diastolic blood pressure (DBP) was 100.2 ± 11.2 mm Hg. All the three blood pressure parameters [SBP, DBP and mean arterial pressure (MAP)] were significantly higher among individuals with lower 25(OH)D levels. The P values for trends in SBP, DBP and MAP were 0.009, 0.01 and 0.007, respectively. Though all the three blood pressure parameters (SBP, DBP and MAP) were higher among individuals with higher BMIs, they were not achieving statistical significance. Increasing trends in PRA and PAC were noticed with lower 25(OH)D and higher BMI levels. CONCLUSION: Vitamin D deficiency and obesity are associated with stimulation of RAAS activity. Vitamin D supplementation along with weight loss may be studied as a therapeutic strategy to reduce tissue RAS activity in individualswith Vitamin D deficiency and obesity.
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spelling pubmed-32301052011-12-05 Renin–angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study Kota, Sunil Kumar Kota, Siva Krishna Jammula, Sruti Meher, Lalit Kumar Panda, Sandip Tripathy, Prabhas Rranjan Modi, Kirtikumar D. Indian J Endocrinol Metab Original Article BACKGROUND: Elevated renin–angiotensin–aldosterone system (RAAS) activity is an important mechanism in the development of hypertension. Both obesity and 25-hydroxy vitamin D [25(OH)D] deficiency have been associated with hypertension and augmented renin-angiotensin system (RAS) activity. We tried to test the hypothesis that vitamin D deficiency and obesity are associated with increased RAS activity in Indian patients with hypertension. MATERIALS AND METHODS: Fifty newly detected hypertensive patients were screened. Patients with secondary hypertension, chronic kidney disease, or coronary artery disease were excluded. Patients underwent measurement of vitamin D and plasma renin and plasma aldosterone concentrations. They were divided into three groups according to their baseline body mass index (BMI; normal <25 kg/m(2), overweight 25–29.9 kg/m(2) and obese ≥30 kg/m(2)) and 25(OH)D levels (deficient <20 ng/ml, insufficient 20–29 ng/ml and optimal ≥30 ng/ml). RESULTS: A total of 50 (male:female – 32:18) patients were included, with a mean age of 49.5 ± 7.8 years, mean BMI of 28.3 ± 3.4 kg/m(2) and a mean 25(OH)D concentration of 18.5 ± 6.4 ng/ml. Mean systolic blood pressure (SBP) was 162.4 ± 20.2 mm Hg and mean diastolic blood pressure (DBP) was 100.2 ± 11.2 mm Hg. All the three blood pressure parameters [SBP, DBP and mean arterial pressure (MAP)] were significantly higher among individuals with lower 25(OH)D levels. The P values for trends in SBP, DBP and MAP were 0.009, 0.01 and 0.007, respectively. Though all the three blood pressure parameters (SBP, DBP and MAP) were higher among individuals with higher BMIs, they were not achieving statistical significance. Increasing trends in PRA and PAC were noticed with lower 25(OH)D and higher BMI levels. CONCLUSION: Vitamin D deficiency and obesity are associated with stimulation of RAAS activity. Vitamin D supplementation along with weight loss may be studied as a therapeutic strategy to reduce tissue RAS activity in individualswith Vitamin D deficiency and obesity. Medknow Publications & Media Pvt Ltd 2011-10 /pmc/articles/PMC3230105/ /pubmed/22145146 http://dx.doi.org/10.4103/2230-8210.86985 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kota, Sunil Kumar
Kota, Siva Krishna
Jammula, Sruti
Meher, Lalit Kumar
Panda, Sandip
Tripathy, Prabhas Rranjan
Modi, Kirtikumar D.
Renin–angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study
title Renin–angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study
title_full Renin–angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study
title_fullStr Renin–angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study
title_full_unstemmed Renin–angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study
title_short Renin–angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study
title_sort renin–angiotensin system activity in vitamin d deficient, obese individuals with hypertension: an urban indian study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230105/
https://www.ncbi.nlm.nih.gov/pubmed/22145146
http://dx.doi.org/10.4103/2230-8210.86985
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