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Adiposity and weight change in mid-life in relation to healthy survival after age 70 in women: prospective cohort study

Objective To examine the hypothesis that mid-life adiposity is associated with a reduced probability of maintaining an optimal health status among those who survive to older ages. Design Prospective cohort study. Setting The Nurses’ Health Study, United States. Participants 17 065 women who survived...

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Autores principales: Sun, Qi, Townsend, Mary K, Okereke, Olivia I, Franco, Oscar H, Hu, Frank B, Grodstein, Francine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230231/
https://www.ncbi.nlm.nih.gov/pubmed/19789407
http://dx.doi.org/10.1136/bmj.b3796
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author Sun, Qi
Townsend, Mary K
Okereke, Olivia I
Franco, Oscar H
Hu, Frank B
Grodstein, Francine
author_facet Sun, Qi
Townsend, Mary K
Okereke, Olivia I
Franco, Oscar H
Hu, Frank B
Grodstein, Francine
author_sort Sun, Qi
collection PubMed
description Objective To examine the hypothesis that mid-life adiposity is associated with a reduced probability of maintaining an optimal health status among those who survive to older ages. Design Prospective cohort study. Setting The Nurses’ Health Study, United States. Participants 17 065 women who survived until at least the age of 70, provided information on occurrence of chronic disease, cognitive function, physical function, and mental health at older ages, and were free from major chronic diseases at mid-life (mean age was 50 at baseline in 1976). Main outcome measures Healthy survival to age 70 and over was defined as having no history of 11 major chronic diseases and having no substantial cognitive, physical, or mental limitations. Results Of the women who survived until at least age 70, 1686 (9.9%) met our criteria for healthy survival. Increased body mass index (BMI) at baseline was significantly associated with linearly reduced odds of healthy survival compared with usual survival, after adjustment for various lifestyle and dietary variables (P<0.001 for trend). Compared with lean women (BMI 18.5-22.9), obese women (BMI ≥30) had 79% lower odds of healthy survival (odds ratio 0.21, 95% confidence interval 0.15 to 0.29). In addition, the more weight gained from age 18 until mid-life, the less likely was healthy survival after the age of 70. The lowest odds of healthy survival were among women who were overweight (BMI ≥25) at age 18 and gained ≥10 kg weight (0.18, 0.09 to 0.36), relative to women who were lean (BMI 18.5-22.9) and maintained a stable weight. Conclusions These data provide evidence that adiposity in mid-life is strongly related to a reduced probability of healthy survival among women who live to older ages, and emphasise the importance of maintaining a healthy weight from early adulthood.
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spelling pubmed-32302312011-12-08 Adiposity and weight change in mid-life in relation to healthy survival after age 70 in women: prospective cohort study Sun, Qi Townsend, Mary K Okereke, Olivia I Franco, Oscar H Hu, Frank B Grodstein, Francine BMJ Research Objective To examine the hypothesis that mid-life adiposity is associated with a reduced probability of maintaining an optimal health status among those who survive to older ages. Design Prospective cohort study. Setting The Nurses’ Health Study, United States. Participants 17 065 women who survived until at least the age of 70, provided information on occurrence of chronic disease, cognitive function, physical function, and mental health at older ages, and were free from major chronic diseases at mid-life (mean age was 50 at baseline in 1976). Main outcome measures Healthy survival to age 70 and over was defined as having no history of 11 major chronic diseases and having no substantial cognitive, physical, or mental limitations. Results Of the women who survived until at least age 70, 1686 (9.9%) met our criteria for healthy survival. Increased body mass index (BMI) at baseline was significantly associated with linearly reduced odds of healthy survival compared with usual survival, after adjustment for various lifestyle and dietary variables (P<0.001 for trend). Compared with lean women (BMI 18.5-22.9), obese women (BMI ≥30) had 79% lower odds of healthy survival (odds ratio 0.21, 95% confidence interval 0.15 to 0.29). In addition, the more weight gained from age 18 until mid-life, the less likely was healthy survival after the age of 70. The lowest odds of healthy survival were among women who were overweight (BMI ≥25) at age 18 and gained ≥10 kg weight (0.18, 0.09 to 0.36), relative to women who were lean (BMI 18.5-22.9) and maintained a stable weight. Conclusions These data provide evidence that adiposity in mid-life is strongly related to a reduced probability of healthy survival among women who live to older ages, and emphasise the importance of maintaining a healthy weight from early adulthood. BMJ Publishing Group Ltd. 2009-09-29 /pmc/articles/PMC3230231/ /pubmed/19789407 http://dx.doi.org/10.1136/bmj.b3796 Text en This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
spellingShingle Research
Sun, Qi
Townsend, Mary K
Okereke, Olivia I
Franco, Oscar H
Hu, Frank B
Grodstein, Francine
Adiposity and weight change in mid-life in relation to healthy survival after age 70 in women: prospective cohort study
title Adiposity and weight change in mid-life in relation to healthy survival after age 70 in women: prospective cohort study
title_full Adiposity and weight change in mid-life in relation to healthy survival after age 70 in women: prospective cohort study
title_fullStr Adiposity and weight change in mid-life in relation to healthy survival after age 70 in women: prospective cohort study
title_full_unstemmed Adiposity and weight change in mid-life in relation to healthy survival after age 70 in women: prospective cohort study
title_short Adiposity and weight change in mid-life in relation to healthy survival after age 70 in women: prospective cohort study
title_sort adiposity and weight change in mid-life in relation to healthy survival after age 70 in women: prospective cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230231/
https://www.ncbi.nlm.nih.gov/pubmed/19789407
http://dx.doi.org/10.1136/bmj.b3796
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