Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

Small-molecule protein kinase inhibitors are central tools for elucidating cellular signaling pathways and are promising therapeutic agents. Due to evolutionary conservation of the ATP-binding site, most kinase inhibitors that target this site promiscuously inhibit multiple kinases. Interpretation o...

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Detalles Bibliográficos
Autores principales: Anastassiadis, Theonie, Deacon, Sean W., Devarajan, Karthik, Ma, Haiching, Peterson, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230241/
https://www.ncbi.nlm.nih.gov/pubmed/22037377
http://dx.doi.org/10.1038/nbt.2017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230241/
https://www.ncbi.nlm.nih.gov/pubmed/22037377
http://dx.doi.org/10.1038/nbt.2017

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