In Utero and Lactational Exposure to PCBs in Mice: Adult Offspring Show Altered Learning and Memory Depending on Cyp1a2 and Ahr Genotypes

Background: Both coplanar and noncoplanar polychlorinated biphenyls (PCBs) exhibit neurotoxic effects in animal studies, but individual congeners do not always produce the same effects as PCB mixtures. Humans genetically have > 60-fold differences in hepatic cytochrome P450 1A2 (CYP1A2)-uninduced...

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Detalles Bibliográficos
Autores principales: Curran, Christine P., Nebert, Daniel W., Genter, Mary Beth, Patel, Krishna V., Schaefer, Tori L., Skelton, Matthew R., Williams, Michael T., Vorhees, Charles V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230394/
https://www.ncbi.nlm.nih.gov/pubmed/21571617
http://dx.doi.org/10.1289/ehp.1002965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230394/
https://www.ncbi.nlm.nih.gov/pubmed/21571617
http://dx.doi.org/10.1289/ehp.1002965

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