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Characterization of Abcc4 Gene Amplification in Stepwise-Selected Mouse J774 Macrophages Resistant to the Topoisomerase II Inhibitor Ciprofloxacin

Exposure of J774 mouse macrophages to stepwise increasing concentrations of ciprofloxacin, an antibiotic inhibiting bacterial topoisomerases, selects for resistant cells that overexpress the efflux transporter Abcc4 (Marquez et al. [2009] Antimicrob. Agents Chemother. 53: 2410–2416), encoded by the...

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Detalles Bibliográficos
Autores principales:	Marquez, Béatrice, Ameye, Geneviève, Vallet, Coralie M., Tulkens, Paul M., Poirel, Hélène A., Van Bambeke, Françoise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230599/ https://www.ncbi.nlm.nih.gov/pubmed/22162766 http://dx.doi.org/10.1371/journal.pone.0028368

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