A Shared Structural Solution for Neutralizing Ebolaviruses

Sudan virus (genus ebolavirus) is lethal, yet no monoclonal antibody is known to neutralize it. Here we describe antibody 16F6 that neutralizes Sudan virus and present its structure bound to the trimeric viral glycoprotein. Unexpectedly, the 16F6 epitope overlaps that of KZ52, the only other antibod...

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Autores principales: Dias, João M., Kuehne, Ana I., Abelson, Dafna M., Bale, Shridhar, Wong, Anthony C., Halfmann, Peter, Muhammad, Majidat A., Fusco, Marnie L., Zak, Samantha E., Kang, Eugene, Kawaoka, Yoshihiro, Chandran, Kartik, Dye, John M., Saphire, Erica Ollmann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230659/
https://www.ncbi.nlm.nih.gov/pubmed/22101933
http://dx.doi.org/10.1038/nsmb.2150
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author Dias, João M.
Kuehne, Ana I.
Abelson, Dafna M.
Bale, Shridhar
Wong, Anthony C.
Halfmann, Peter
Muhammad, Majidat A.
Fusco, Marnie L.
Zak, Samantha E.
Kang, Eugene
Kawaoka, Yoshihiro
Chandran, Kartik
Dye, John M.
Saphire, Erica Ollmann
author_facet Dias, João M.
Kuehne, Ana I.
Abelson, Dafna M.
Bale, Shridhar
Wong, Anthony C.
Halfmann, Peter
Muhammad, Majidat A.
Fusco, Marnie L.
Zak, Samantha E.
Kang, Eugene
Kawaoka, Yoshihiro
Chandran, Kartik
Dye, John M.
Saphire, Erica Ollmann
author_sort Dias, João M.
collection PubMed
description Sudan virus (genus ebolavirus) is lethal, yet no monoclonal antibody is known to neutralize it. Here we describe antibody 16F6 that neutralizes Sudan virus and present its structure bound to the trimeric viral glycoprotein. Unexpectedly, the 16F6 epitope overlaps that of KZ52, the only other antibody against the GP(1,2) core to be visualized. Further, both antibodies against this key GP1–GP2-bridging epitope neutralize at a post-internalization step, likely fusion.
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spelling pubmed-32306592012-06-01 A Shared Structural Solution for Neutralizing Ebolaviruses Dias, João M. Kuehne, Ana I. Abelson, Dafna M. Bale, Shridhar Wong, Anthony C. Halfmann, Peter Muhammad, Majidat A. Fusco, Marnie L. Zak, Samantha E. Kang, Eugene Kawaoka, Yoshihiro Chandran, Kartik Dye, John M. Saphire, Erica Ollmann Nat Struct Mol Biol Article Sudan virus (genus ebolavirus) is lethal, yet no monoclonal antibody is known to neutralize it. Here we describe antibody 16F6 that neutralizes Sudan virus and present its structure bound to the trimeric viral glycoprotein. Unexpectedly, the 16F6 epitope overlaps that of KZ52, the only other antibody against the GP(1,2) core to be visualized. Further, both antibodies against this key GP1–GP2-bridging epitope neutralize at a post-internalization step, likely fusion. 2011-11-20 /pmc/articles/PMC3230659/ /pubmed/22101933 http://dx.doi.org/10.1038/nsmb.2150 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Dias, João M.
Kuehne, Ana I.
Abelson, Dafna M.
Bale, Shridhar
Wong, Anthony C.
Halfmann, Peter
Muhammad, Majidat A.
Fusco, Marnie L.
Zak, Samantha E.
Kang, Eugene
Kawaoka, Yoshihiro
Chandran, Kartik
Dye, John M.
Saphire, Erica Ollmann
A Shared Structural Solution for Neutralizing Ebolaviruses
title A Shared Structural Solution for Neutralizing Ebolaviruses
title_full A Shared Structural Solution for Neutralizing Ebolaviruses
title_fullStr A Shared Structural Solution for Neutralizing Ebolaviruses
title_full_unstemmed A Shared Structural Solution for Neutralizing Ebolaviruses
title_short A Shared Structural Solution for Neutralizing Ebolaviruses
title_sort shared structural solution for neutralizing ebolaviruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230659/
https://www.ncbi.nlm.nih.gov/pubmed/22101933
http://dx.doi.org/10.1038/nsmb.2150
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