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The Molecular Biology of Feline Immunodeficiency Virus (FIV)

Feline immunodeficiency virus (FIV) is widespread in feline populations and causes an AIDS-like illness in domestic cats. It is highly prevalent in several endangered feline species. In domestic cats FIV infection is a valuable small animal model for HIV infection. In recent years there has been sa...

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Detalles Bibliográficos
Autores principales: Kenyon, Julia C., Lever, Andrew M. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230847/
https://www.ncbi.nlm.nih.gov/pubmed/22163340
http://dx.doi.org/10.3390/v3112192
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author Kenyon, Julia C.
Lever, Andrew M. L.
author_facet Kenyon, Julia C.
Lever, Andrew M. L.
author_sort Kenyon, Julia C.
collection PubMed
description Feline immunodeficiency virus (FIV) is widespread in feline populations and causes an AIDS-like illness in domestic cats. It is highly prevalent in several endangered feline species. In domestic cats FIV infection is a valuable small animal model for HIV infection. In recent years there has been sa significant increase in interest in FIV, in part to exploit this, but also because of the potential it has as a human gene therapy vector. Though much less studied than HIV there are many parallels in the replication of the two viruses, but also important differences and, despite their likely common origin, the viruses have in some cases used alternative strategies to overcome similar problems. Recent advances in understanding the structure and function of FIV RNA and proteins and their interactions has enhanced our knowledge of FIV replication significantly, however, there are still many gaps. This review summarizes our current knowledge of FIV molecular biology and its similarities with, and differences from, other lentiviruses.
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spelling pubmed-32308472011-12-12 The Molecular Biology of Feline Immunodeficiency Virus (FIV) Kenyon, Julia C. Lever, Andrew M. L. Viruses Review Feline immunodeficiency virus (FIV) is widespread in feline populations and causes an AIDS-like illness in domestic cats. It is highly prevalent in several endangered feline species. In domestic cats FIV infection is a valuable small animal model for HIV infection. In recent years there has been sa significant increase in interest in FIV, in part to exploit this, but also because of the potential it has as a human gene therapy vector. Though much less studied than HIV there are many parallels in the replication of the two viruses, but also important differences and, despite their likely common origin, the viruses have in some cases used alternative strategies to overcome similar problems. Recent advances in understanding the structure and function of FIV RNA and proteins and their interactions has enhanced our knowledge of FIV replication significantly, however, there are still many gaps. This review summarizes our current knowledge of FIV molecular biology and its similarities with, and differences from, other lentiviruses. Molecular Diversity Preservation International (MDPI) 2011-11-09 /pmc/articles/PMC3230847/ /pubmed/22163340 http://dx.doi.org/10.3390/v3112192 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Kenyon, Julia C.
Lever, Andrew M. L.
The Molecular Biology of Feline Immunodeficiency Virus (FIV)
title The Molecular Biology of Feline Immunodeficiency Virus (FIV)
title_full The Molecular Biology of Feline Immunodeficiency Virus (FIV)
title_fullStr The Molecular Biology of Feline Immunodeficiency Virus (FIV)
title_full_unstemmed The Molecular Biology of Feline Immunodeficiency Virus (FIV)
title_short The Molecular Biology of Feline Immunodeficiency Virus (FIV)
title_sort molecular biology of feline immunodeficiency virus (fiv)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230847/
https://www.ncbi.nlm.nih.gov/pubmed/22163340
http://dx.doi.org/10.3390/v3112192
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