Hepatitis C Virus Assembly Imaging

Hepatitis C Virus (HCV) assembly process is the least understood step in the virus life cycle. The functional data revealed by forward and reverse genetics indicated that both structural and non-structural proteins are involved in the assembly process. Using confocal and electron microscopy differen...

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Detalles Bibliográficos
Autores principales: Popescu, Costin-Ioan, Rouillé, Yves, Dubuisson, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230850/
https://www.ncbi.nlm.nih.gov/pubmed/22163343
http://dx.doi.org/10.3390/v3112238
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author Popescu, Costin-Ioan
Rouillé, Yves
Dubuisson, Jean
author_facet Popescu, Costin-Ioan
Rouillé, Yves
Dubuisson, Jean
author_sort Popescu, Costin-Ioan
collection PubMed
description Hepatitis C Virus (HCV) assembly process is the least understood step in the virus life cycle. The functional data revealed by forward and reverse genetics indicated that both structural and non-structural proteins are involved in the assembly process. Using confocal and electron microscopy different groups determined the subcellular localization of different viral proteins and they identified the lipid droplets (LDs) as the potential viral assembly site. Here, we aim to review the mechanisms that govern the viral proteins recruitment to LDs and discuss the current model of HCV assembly process. Based on previous examples, this review will also discuss advanced imaging techniques as potential means to extend our present knowledge of HCV assembly process.
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spelling pubmed-32308502011-12-12 Hepatitis C Virus Assembly Imaging Popescu, Costin-Ioan Rouillé, Yves Dubuisson, Jean Viruses Review Hepatitis C Virus (HCV) assembly process is the least understood step in the virus life cycle. The functional data revealed by forward and reverse genetics indicated that both structural and non-structural proteins are involved in the assembly process. Using confocal and electron microscopy different groups determined the subcellular localization of different viral proteins and they identified the lipid droplets (LDs) as the potential viral assembly site. Here, we aim to review the mechanisms that govern the viral proteins recruitment to LDs and discuss the current model of HCV assembly process. Based on previous examples, this review will also discuss advanced imaging techniques as potential means to extend our present knowledge of HCV assembly process. Molecular Diversity Preservation International (MDPI) 2011-11-15 /pmc/articles/PMC3230850/ /pubmed/22163343 http://dx.doi.org/10.3390/v3112238 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Popescu, Costin-Ioan
Rouillé, Yves
Dubuisson, Jean
Hepatitis C Virus Assembly Imaging
title Hepatitis C Virus Assembly Imaging
title_full Hepatitis C Virus Assembly Imaging
title_fullStr Hepatitis C Virus Assembly Imaging
title_full_unstemmed Hepatitis C Virus Assembly Imaging
title_short Hepatitis C Virus Assembly Imaging
title_sort hepatitis c virus assembly imaging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230850/
https://www.ncbi.nlm.nih.gov/pubmed/22163343
http://dx.doi.org/10.3390/v3112238
work_keys_str_mv AT popescucostinioan hepatitiscvirusassemblyimaging
AT rouilleyves hepatitiscvirusassemblyimaging
AT dubuissonjean hepatitiscvirusassemblyimaging

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