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Stress Granules in the Viral Replication Cycle

As intracellular parasites, viruses require a host cell in order to replicate. However, they face a series of cellular responses against infection. One of these responses is the activation of the double-stranded RNA (dsRNA)-activated protein kinase R (PKR). PKR phosphorylates the α subunit of eukary...

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Detalles Bibliográficos
Autores principales: Montero, Hilda, Trujillo-Alonso, Vicenta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230854/
https://www.ncbi.nlm.nih.gov/pubmed/22163347
http://dx.doi.org/10.3390/v3112328
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author Montero, Hilda
Trujillo-Alonso, Vicenta
author_facet Montero, Hilda
Trujillo-Alonso, Vicenta
author_sort Montero, Hilda
collection PubMed
description As intracellular parasites, viruses require a host cell in order to replicate. However, they face a series of cellular responses against infection. One of these responses is the activation of the double-stranded RNA (dsRNA)-activated protein kinase R (PKR). PKR phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF2α), which in turn results in global protein synthesis inhibition and formation of stress granules (SGs). Recent studies have shown that SGs can interfere with the replicative cycle of certain viruses. This review addresses how viruses have evolved different control strategies at the SG level to ensure an efficient replication cycle during the cellular stress response triggered by the viral infection.
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spelling pubmed-32308542011-12-12 Stress Granules in the Viral Replication Cycle Montero, Hilda Trujillo-Alonso, Vicenta Viruses Review As intracellular parasites, viruses require a host cell in order to replicate. However, they face a series of cellular responses against infection. One of these responses is the activation of the double-stranded RNA (dsRNA)-activated protein kinase R (PKR). PKR phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF2α), which in turn results in global protein synthesis inhibition and formation of stress granules (SGs). Recent studies have shown that SGs can interfere with the replicative cycle of certain viruses. This review addresses how viruses have evolved different control strategies at the SG level to ensure an efficient replication cycle during the cellular stress response triggered by the viral infection. Molecular Diversity Preservation International (MDPI) 2011-11-18 /pmc/articles/PMC3230854/ /pubmed/22163347 http://dx.doi.org/10.3390/v3112328 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Montero, Hilda
Trujillo-Alonso, Vicenta
Stress Granules in the Viral Replication Cycle
title Stress Granules in the Viral Replication Cycle
title_full Stress Granules in the Viral Replication Cycle
title_fullStr Stress Granules in the Viral Replication Cycle
title_full_unstemmed Stress Granules in the Viral Replication Cycle
title_short Stress Granules in the Viral Replication Cycle
title_sort stress granules in the viral replication cycle
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230854/
https://www.ncbi.nlm.nih.gov/pubmed/22163347
http://dx.doi.org/10.3390/v3112328
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