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Manganese(III) Porphyrin-based Potentiometric Sensors for Diclofenac Assay in Pharmaceutical Preparations

Two manganese(III) porphyrins: manganese(III) tetraphenylporphyrin chloride and manganese(III)-tetrakis(3-hydroxyphenyl)porphyrin chloride were tested as ionophores for the construction of new diclofenac–selective electrodes. The electroactive material was incorporated either in PVC or a sol–gel mat...

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Autores principales: Vlascici, Dana, Pruneanu, Stela, Olenic, Liliana, Pogacean, Florina, Ostafe, Vasile, Chiriac, Vlad, Pica, Elena Maria, Bolundut, Liviu Calin, Nica, Luminita, Fagadar-Cosma, Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230948/
https://www.ncbi.nlm.nih.gov/pubmed/22163384
http://dx.doi.org/10.3390/s101008850
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author Vlascici, Dana
Pruneanu, Stela
Olenic, Liliana
Pogacean, Florina
Ostafe, Vasile
Chiriac, Vlad
Pica, Elena Maria
Bolundut, Liviu Calin
Nica, Luminita
Fagadar-Cosma, Eugenia
author_facet Vlascici, Dana
Pruneanu, Stela
Olenic, Liliana
Pogacean, Florina
Ostafe, Vasile
Chiriac, Vlad
Pica, Elena Maria
Bolundut, Liviu Calin
Nica, Luminita
Fagadar-Cosma, Eugenia
author_sort Vlascici, Dana
collection PubMed
description Two manganese(III) porphyrins: manganese(III) tetraphenylporphyrin chloride and manganese(III)-tetrakis(3-hydroxyphenyl)porphyrin chloride were tested as ionophores for the construction of new diclofenac–selective electrodes. The electroactive material was incorporated either in PVC or a sol–gel matrix. The effect of different plasticizers and additives (anionic and cationic) on the potentiometric response was studied. The best results were obtained for the PVC membrane plasticized with dioctylphtalate and having sodium tetraphenylborate as a lipophilic anionic additive incorporated. The sensor response was linear in the concentration range 3 × 10(−6) – 1 × 10(−2) M with a slope of −59.7 mV/dec diclofenac, a detection limit of 1.5 × 10(−6) M and very good selectivity coefficients. It was used for the determination of diclofenac in pharmaceutical preparations, by direct potentiometry. The results were compared with those obtained by the HPLC reference method and a good agreement was found between the two methods.
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spelling pubmed-32309482011-12-07 Manganese(III) Porphyrin-based Potentiometric Sensors for Diclofenac Assay in Pharmaceutical Preparations Vlascici, Dana Pruneanu, Stela Olenic, Liliana Pogacean, Florina Ostafe, Vasile Chiriac, Vlad Pica, Elena Maria Bolundut, Liviu Calin Nica, Luminita Fagadar-Cosma, Eugenia Sensors (Basel) Article Two manganese(III) porphyrins: manganese(III) tetraphenylporphyrin chloride and manganese(III)-tetrakis(3-hydroxyphenyl)porphyrin chloride were tested as ionophores for the construction of new diclofenac–selective electrodes. The electroactive material was incorporated either in PVC or a sol–gel matrix. The effect of different plasticizers and additives (anionic and cationic) on the potentiometric response was studied. The best results were obtained for the PVC membrane plasticized with dioctylphtalate and having sodium tetraphenylborate as a lipophilic anionic additive incorporated. The sensor response was linear in the concentration range 3 × 10(−6) – 1 × 10(−2) M with a slope of −59.7 mV/dec diclofenac, a detection limit of 1.5 × 10(−6) M and very good selectivity coefficients. It was used for the determination of diclofenac in pharmaceutical preparations, by direct potentiometry. The results were compared with those obtained by the HPLC reference method and a good agreement was found between the two methods. Molecular Diversity Preservation International (MDPI) 2010-09-28 /pmc/articles/PMC3230948/ /pubmed/22163384 http://dx.doi.org/10.3390/s101008850 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Vlascici, Dana
Pruneanu, Stela
Olenic, Liliana
Pogacean, Florina
Ostafe, Vasile
Chiriac, Vlad
Pica, Elena Maria
Bolundut, Liviu Calin
Nica, Luminita
Fagadar-Cosma, Eugenia
Manganese(III) Porphyrin-based Potentiometric Sensors for Diclofenac Assay in Pharmaceutical Preparations
title Manganese(III) Porphyrin-based Potentiometric Sensors for Diclofenac Assay in Pharmaceutical Preparations
title_full Manganese(III) Porphyrin-based Potentiometric Sensors for Diclofenac Assay in Pharmaceutical Preparations
title_fullStr Manganese(III) Porphyrin-based Potentiometric Sensors for Diclofenac Assay in Pharmaceutical Preparations
title_full_unstemmed Manganese(III) Porphyrin-based Potentiometric Sensors for Diclofenac Assay in Pharmaceutical Preparations
title_short Manganese(III) Porphyrin-based Potentiometric Sensors for Diclofenac Assay in Pharmaceutical Preparations
title_sort manganese(iii) porphyrin-based potentiometric sensors for diclofenac assay in pharmaceutical preparations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230948/
https://www.ncbi.nlm.nih.gov/pubmed/22163384
http://dx.doi.org/10.3390/s101008850
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