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Intelligent Chiral Sensing Based on Supramolecular and Interfacial Concepts

Of the known intelligently-operating systems, the majority can undoubtedly be classed as being of biological origin. One of the notable differences between biological and artificial systems is the important fact that biological materials consist mostly of chiral molecules. While most biochemical pro...

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Autores principales: Ariga, Katsuhiko, Richards, Gary J., Ishihara, Shinsuke, Izawa, Hironori, Hill, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231122/
https://www.ncbi.nlm.nih.gov/pubmed/22163577
http://dx.doi.org/10.3390/s100706796
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author Ariga, Katsuhiko
Richards, Gary J.
Ishihara, Shinsuke
Izawa, Hironori
Hill, Jonathan P.
author_facet Ariga, Katsuhiko
Richards, Gary J.
Ishihara, Shinsuke
Izawa, Hironori
Hill, Jonathan P.
author_sort Ariga, Katsuhiko
collection PubMed
description Of the known intelligently-operating systems, the majority can undoubtedly be classed as being of biological origin. One of the notable differences between biological and artificial systems is the important fact that biological materials consist mostly of chiral molecules. While most biochemical processes routinely discriminate chiral molecules, differentiation between chiral molecules in artificial systems is currently one of the challenging subjects in the field of molecular recognition. Therefore, one of the important challenges for intelligent man-made sensors is to prepare a sensing system that can discriminate chiral molecules. Because intermolecular interactions and detection at surfaces are respectively parts of supramolecular chemistry and interfacial science, chiral sensing based on supramolecular and interfacial concepts is a significant topic. In this review, we briefly summarize recent advances in these fields, including supramolecular hosts for color detection on chiral sensing, indicator-displacement assays, kinetic resolution in supramolecular reactions with analyses by mass spectrometry, use of chiral shape-defined polymers, such as dynamic helical polymers, molecular imprinting, thin films on surfaces of devices such as QCM, functional electrodes, FET, and SPR, the combined technique of magnetic resonance imaging and immunoassay, and chiral detection using scanning tunneling microscopy and cantilever technology. In addition, we will discuss novel concepts in recent research including the use of achiral reagents for chiral sensing with NMR, and mechanical control of chiral sensing. The importance of integration of chiral sensing systems with rapidly developing nanotechnology and nanomaterials is also emphasized.
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spelling pubmed-32311222011-12-07 Intelligent Chiral Sensing Based on Supramolecular and Interfacial Concepts Ariga, Katsuhiko Richards, Gary J. Ishihara, Shinsuke Izawa, Hironori Hill, Jonathan P. Sensors (Basel) Review Of the known intelligently-operating systems, the majority can undoubtedly be classed as being of biological origin. One of the notable differences between biological and artificial systems is the important fact that biological materials consist mostly of chiral molecules. While most biochemical processes routinely discriminate chiral molecules, differentiation between chiral molecules in artificial systems is currently one of the challenging subjects in the field of molecular recognition. Therefore, one of the important challenges for intelligent man-made sensors is to prepare a sensing system that can discriminate chiral molecules. Because intermolecular interactions and detection at surfaces are respectively parts of supramolecular chemistry and interfacial science, chiral sensing based on supramolecular and interfacial concepts is a significant topic. In this review, we briefly summarize recent advances in these fields, including supramolecular hosts for color detection on chiral sensing, indicator-displacement assays, kinetic resolution in supramolecular reactions with analyses by mass spectrometry, use of chiral shape-defined polymers, such as dynamic helical polymers, molecular imprinting, thin films on surfaces of devices such as QCM, functional electrodes, FET, and SPR, the combined technique of magnetic resonance imaging and immunoassay, and chiral detection using scanning tunneling microscopy and cantilever technology. In addition, we will discuss novel concepts in recent research including the use of achiral reagents for chiral sensing with NMR, and mechanical control of chiral sensing. The importance of integration of chiral sensing systems with rapidly developing nanotechnology and nanomaterials is also emphasized. Molecular Diversity Preservation International (MDPI) 2010-07-13 /pmc/articles/PMC3231122/ /pubmed/22163577 http://dx.doi.org/10.3390/s100706796 Text en © 2010 by the authors licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Ariga, Katsuhiko
Richards, Gary J.
Ishihara, Shinsuke
Izawa, Hironori
Hill, Jonathan P.
Intelligent Chiral Sensing Based on Supramolecular and Interfacial Concepts
title Intelligent Chiral Sensing Based on Supramolecular and Interfacial Concepts
title_full Intelligent Chiral Sensing Based on Supramolecular and Interfacial Concepts
title_fullStr Intelligent Chiral Sensing Based on Supramolecular and Interfacial Concepts
title_full_unstemmed Intelligent Chiral Sensing Based on Supramolecular and Interfacial Concepts
title_short Intelligent Chiral Sensing Based on Supramolecular and Interfacial Concepts
title_sort intelligent chiral sensing based on supramolecular and interfacial concepts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231122/
https://www.ncbi.nlm.nih.gov/pubmed/22163577
http://dx.doi.org/10.3390/s100706796
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