Cargando…

Fluorescent Chemosensors for Toxic Organophosphorus Pesticides: A Review

Many organophosphorus (OP) based compounds are highly toxic and powerful inhibitors of cholinesterases that generate serious environmental and human health concerns. Organothiophosphates with a thiophosphoryl (P=S) functional group constitute a broad class of these widely used pesticides. They are r...

Descripción completa

Detalles Bibliográficos
Autores principales: Obare, Sherine O., De, Chandrima, Guo, Wen, Haywood, Tajay L., Samuels, Tova A., Adams, Clara P., Masika, Noah O., Murray, Desmond H., Anderson, Ginger A., Campbell, Keith, Fletcher, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231149/
https://www.ncbi.nlm.nih.gov/pubmed/22163587
http://dx.doi.org/10.3390/s100707018
_version_ 1782218155091820544
author Obare, Sherine O.
De, Chandrima
Guo, Wen
Haywood, Tajay L.
Samuels, Tova A.
Adams, Clara P.
Masika, Noah O.
Murray, Desmond H.
Anderson, Ginger A.
Campbell, Keith
Fletcher, Kenneth
author_facet Obare, Sherine O.
De, Chandrima
Guo, Wen
Haywood, Tajay L.
Samuels, Tova A.
Adams, Clara P.
Masika, Noah O.
Murray, Desmond H.
Anderson, Ginger A.
Campbell, Keith
Fletcher, Kenneth
author_sort Obare, Sherine O.
collection PubMed
description Many organophosphorus (OP) based compounds are highly toxic and powerful inhibitors of cholinesterases that generate serious environmental and human health concerns. Organothiophosphates with a thiophosphoryl (P=S) functional group constitute a broad class of these widely used pesticides. They are related to the more reactive phosphoryl (P=O) organophosphates, which include very lethal nerve agents and chemical warfare agents, such as, VX, Soman and Sarin. Unfortunately, widespread and frequent commercial use of OP-based compounds in agricultural lands has resulted in their presence as residues in crops, livestock, and poultry products and also led to their migration into aquifers. Thus, the design of new sensors with improved analyte selectivity and sensitivity is of paramount importance in this area. Herein, we review recent advances in the development of fluorescent chemosensors for toxic OP pesticides and related compounds. We also discuss challenges and progress towards the design of future chemosensors with dual modes for signal transduction.
format Online
Article
Text
id pubmed-3231149
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-32311492011-12-07 Fluorescent Chemosensors for Toxic Organophosphorus Pesticides: A Review Obare, Sherine O. De, Chandrima Guo, Wen Haywood, Tajay L. Samuels, Tova A. Adams, Clara P. Masika, Noah O. Murray, Desmond H. Anderson, Ginger A. Campbell, Keith Fletcher, Kenneth Sensors (Basel) Review Many organophosphorus (OP) based compounds are highly toxic and powerful inhibitors of cholinesterases that generate serious environmental and human health concerns. Organothiophosphates with a thiophosphoryl (P=S) functional group constitute a broad class of these widely used pesticides. They are related to the more reactive phosphoryl (P=O) organophosphates, which include very lethal nerve agents and chemical warfare agents, such as, VX, Soman and Sarin. Unfortunately, widespread and frequent commercial use of OP-based compounds in agricultural lands has resulted in their presence as residues in crops, livestock, and poultry products and also led to their migration into aquifers. Thus, the design of new sensors with improved analyte selectivity and sensitivity is of paramount importance in this area. Herein, we review recent advances in the development of fluorescent chemosensors for toxic OP pesticides and related compounds. We also discuss challenges and progress towards the design of future chemosensors with dual modes for signal transduction. Molecular Diversity Preservation International (MDPI) 2010-07-21 /pmc/articles/PMC3231149/ /pubmed/22163587 http://dx.doi.org/10.3390/s100707018 Text en © 2010 by the authors licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Obare, Sherine O.
De, Chandrima
Guo, Wen
Haywood, Tajay L.
Samuels, Tova A.
Adams, Clara P.
Masika, Noah O.
Murray, Desmond H.
Anderson, Ginger A.
Campbell, Keith
Fletcher, Kenneth
Fluorescent Chemosensors for Toxic Organophosphorus Pesticides: A Review
title Fluorescent Chemosensors for Toxic Organophosphorus Pesticides: A Review
title_full Fluorescent Chemosensors for Toxic Organophosphorus Pesticides: A Review
title_fullStr Fluorescent Chemosensors for Toxic Organophosphorus Pesticides: A Review
title_full_unstemmed Fluorescent Chemosensors for Toxic Organophosphorus Pesticides: A Review
title_short Fluorescent Chemosensors for Toxic Organophosphorus Pesticides: A Review
title_sort fluorescent chemosensors for toxic organophosphorus pesticides: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231149/
https://www.ncbi.nlm.nih.gov/pubmed/22163587
http://dx.doi.org/10.3390/s100707018
work_keys_str_mv AT obaresherineo fluorescentchemosensorsfortoxicorganophosphoruspesticidesareview
AT dechandrima fluorescentchemosensorsfortoxicorganophosphoruspesticidesareview
AT guowen fluorescentchemosensorsfortoxicorganophosphoruspesticidesareview
AT haywoodtajayl fluorescentchemosensorsfortoxicorganophosphoruspesticidesareview
AT samuelstovaa fluorescentchemosensorsfortoxicorganophosphoruspesticidesareview
AT adamsclarap fluorescentchemosensorsfortoxicorganophosphoruspesticidesareview
AT masikanoaho fluorescentchemosensorsfortoxicorganophosphoruspesticidesareview
AT murraydesmondh fluorescentchemosensorsfortoxicorganophosphoruspesticidesareview
AT andersongingera fluorescentchemosensorsfortoxicorganophosphoruspesticidesareview
AT campbellkeith fluorescentchemosensorsfortoxicorganophosphoruspesticidesareview
AT fletcherkenneth fluorescentchemosensorsfortoxicorganophosphoruspesticidesareview