Effects of Al(III) and Nano-Al(13) Species on Malate Dehydrogenase Activity

The effects of different aluminum species on malate dehydrogenase (MDH) activity were investigated by monitoring amperometric i-t curves for the oxidation of NADH at low overpotential using a functionalized multi-wall nanotube (MWNT) modified glass carbon electrode (GCE). The results showed that Al(...

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Detalles Bibliográficos
Autores principales: Yang, Xiaodi, Cai, Ling, Peng, Yu, Li, Huihui, Chen, Rong Fu, Shen, Ren Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231464/
https://www.ncbi.nlm.nih.gov/pubmed/22163924
http://dx.doi.org/10.3390/s110605740
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author Yang, Xiaodi
Cai, Ling
Peng, Yu
Li, Huihui
Chen, Rong Fu
Shen, Ren Fang
author_facet Yang, Xiaodi
Cai, Ling
Peng, Yu
Li, Huihui
Chen, Rong Fu
Shen, Ren Fang
author_sort Yang, Xiaodi
collection PubMed
description The effects of different aluminum species on malate dehydrogenase (MDH) activity were investigated by monitoring amperometric i-t curves for the oxidation of NADH at low overpotential using a functionalized multi-wall nanotube (MWNT) modified glass carbon electrode (GCE). The results showed that Al(III) and Al(13) can activate the enzymatic activity of MDH, and the activation reaches maximum levels as the Al(III) and Al(13) concentration increase. Our study also found that the effects of Al(III) and Al(13) on the activity of MDH depended on the pH value and aluminum speciation. Electrochemical and circular dichroism spectra methods were applied to study the effects of nano-sized aluminum compounds on biomolecules.
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spelling pubmed-32314642011-12-07 Effects of Al(III) and Nano-Al(13) Species on Malate Dehydrogenase Activity Yang, Xiaodi Cai, Ling Peng, Yu Li, Huihui Chen, Rong Fu Shen, Ren Fang Sensors (Basel) Article The effects of different aluminum species on malate dehydrogenase (MDH) activity were investigated by monitoring amperometric i-t curves for the oxidation of NADH at low overpotential using a functionalized multi-wall nanotube (MWNT) modified glass carbon electrode (GCE). The results showed that Al(III) and Al(13) can activate the enzymatic activity of MDH, and the activation reaches maximum levels as the Al(III) and Al(13) concentration increase. Our study also found that the effects of Al(III) and Al(13) on the activity of MDH depended on the pH value and aluminum speciation. Electrochemical and circular dichroism spectra methods were applied to study the effects of nano-sized aluminum compounds on biomolecules. Molecular Diversity Preservation International (MDPI) 2011-05-27 /pmc/articles/PMC3231464/ /pubmed/22163924 http://dx.doi.org/10.3390/s110605740 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yang, Xiaodi
Cai, Ling
Peng, Yu
Li, Huihui
Chen, Rong Fu
Shen, Ren Fang
Effects of Al(III) and Nano-Al(13) Species on Malate Dehydrogenase Activity
title Effects of Al(III) and Nano-Al(13) Species on Malate Dehydrogenase Activity
title_full Effects of Al(III) and Nano-Al(13) Species on Malate Dehydrogenase Activity
title_fullStr Effects of Al(III) and Nano-Al(13) Species on Malate Dehydrogenase Activity
title_full_unstemmed Effects of Al(III) and Nano-Al(13) Species on Malate Dehydrogenase Activity
title_short Effects of Al(III) and Nano-Al(13) Species on Malate Dehydrogenase Activity
title_sort effects of al(iii) and nano-al(13) species on malate dehydrogenase activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231464/
https://www.ncbi.nlm.nih.gov/pubmed/22163924
http://dx.doi.org/10.3390/s110605740
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