Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension

We investigated the effects of chronic mineralocorticoid receptor blockade with eplerenone on the development and progression of hypertension and end organ damage in Dahl salt-sensitive rats. Eplerenone significantly attenuated the progressive rise in systolic blood pressure (SBP) (204 ± 3 vs. 179±3...

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Autores principales: Zhou, Xiaoyan, Crook, Martin F, Sharif-Rodriguez, Wanda, Zhu, Yonghua, Ruben, Zadok, Pan, Yi, Urosevic-Price, Olga, Wang, Li, Flattery, Amy M, Forrest, Gail, Szeto, Daphne, Zhao, Huawei, Roy, Sophie, Forrest, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231850/
https://www.ncbi.nlm.nih.gov/pubmed/21950654
http://dx.doi.org/10.3109/10641963.2011.566956
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author Zhou, Xiaoyan
Crook, Martin F
Sharif-Rodriguez, Wanda
Zhu, Yonghua
Ruben, Zadok
Pan, Yi
Urosevic-Price, Olga
Wang, Li
Flattery, Amy M
Forrest, Gail
Szeto, Daphne
Zhao, Huawei
Roy, Sophie
Forrest, Michael J
author_facet Zhou, Xiaoyan
Crook, Martin F
Sharif-Rodriguez, Wanda
Zhu, Yonghua
Ruben, Zadok
Pan, Yi
Urosevic-Price, Olga
Wang, Li
Flattery, Amy M
Forrest, Gail
Szeto, Daphne
Zhao, Huawei
Roy, Sophie
Forrest, Michael J
author_sort Zhou, Xiaoyan
collection PubMed
description We investigated the effects of chronic mineralocorticoid receptor blockade with eplerenone on the development and progression of hypertension and end organ damage in Dahl salt-sensitive rats. Eplerenone significantly attenuated the progressive rise in systolic blood pressure (SBP) (204 ± 3 vs. 179±3 mmHg, p < 0.05), reduced proteinuria (605.5 ± 29.6 vs. 479.7 ± 26.1 mg/24h, p < 0.05), improved injury scores of glomeruli, tubules, renal interstitium, and vasculature in Dahl salt-sensitive rats fed a high-salt diet. These results demonstrate that mineralocorticoid receptor antagonism provides target organ protection and attenuates the development of elevated blood pressure (BP) in a model of salt-sensitive hypertension.
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spelling pubmed-32318502011-12-09 Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension Zhou, Xiaoyan Crook, Martin F Sharif-Rodriguez, Wanda Zhu, Yonghua Ruben, Zadok Pan, Yi Urosevic-Price, Olga Wang, Li Flattery, Amy M Forrest, Gail Szeto, Daphne Zhao, Huawei Roy, Sophie Forrest, Michael J Clin Exp Hypertens Articles We investigated the effects of chronic mineralocorticoid receptor blockade with eplerenone on the development and progression of hypertension and end organ damage in Dahl salt-sensitive rats. Eplerenone significantly attenuated the progressive rise in systolic blood pressure (SBP) (204 ± 3 vs. 179±3 mmHg, p < 0.05), reduced proteinuria (605.5 ± 29.6 vs. 479.7 ± 26.1 mg/24h, p < 0.05), improved injury scores of glomeruli, tubules, renal interstitium, and vasculature in Dahl salt-sensitive rats fed a high-salt diet. These results demonstrate that mineralocorticoid receptor antagonism provides target organ protection and attenuates the development of elevated blood pressure (BP) in a model of salt-sensitive hypertension. Informa Healthcare 2011-12 2011-09-27 /pmc/articles/PMC3231850/ /pubmed/21950654 http://dx.doi.org/10.3109/10641963.2011.566956 Text en © Informa Healthcare USA, Inc http://creativecommons.org/licenses/by/2.0/ This is an open access article distributed under the Supplemental Terms and Conditions for iOpenAccess articles published in Informa Healthcare journals (http://www.informaworld.com/mpp/uploads/iopenaccess_tcs.pdf) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Zhou, Xiaoyan
Crook, Martin F
Sharif-Rodriguez, Wanda
Zhu, Yonghua
Ruben, Zadok
Pan, Yi
Urosevic-Price, Olga
Wang, Li
Flattery, Amy M
Forrest, Gail
Szeto, Daphne
Zhao, Huawei
Roy, Sophie
Forrest, Michael J
Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension
title Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension
title_full Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension
title_fullStr Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension
title_full_unstemmed Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension
title_short Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension
title_sort chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231850/
https://www.ncbi.nlm.nih.gov/pubmed/21950654
http://dx.doi.org/10.3109/10641963.2011.566956
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