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Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors

BACKGROUND: Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL). Many side effects of radiotherapy are believed to be associated with increased oxidative stress and inflammation due to the generation of reactive oxygen species during radiotherapy. Hydro...

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Autores principales: Kang, Ki-Mun, Kang, Young-Nam, Choi, Ihil-Bong, Gu, Yeunhwa, Kawamura, Tomohiro, Toyoda, Yoshiya, Nakao, Atsunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231938/
https://www.ncbi.nlm.nih.gov/pubmed/22146004
http://dx.doi.org/10.1186/2045-9912-1-11
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author Kang, Ki-Mun
Kang, Young-Nam
Choi, Ihil-Bong
Gu, Yeunhwa
Kawamura, Tomohiro
Toyoda, Yoshiya
Nakao, Atsunori
author_facet Kang, Ki-Mun
Kang, Young-Nam
Choi, Ihil-Bong
Gu, Yeunhwa
Kawamura, Tomohiro
Toyoda, Yoshiya
Nakao, Atsunori
author_sort Kang, Ki-Mun
collection PubMed
description BACKGROUND: Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL). Many side effects of radiotherapy are believed to be associated with increased oxidative stress and inflammation due to the generation of reactive oxygen species during radiotherapy. Hydrogen can be administered as a therapeutic medical gas, has antioxidant properties, and reduces inflammation in tissues. This study examined whether hydrogen treatment, in the form of hydrogen-supplemented water, improved QOL in patients receiving radiotherapy. METHODS: A randomized, placebo-controlled study was performed to evaluate the effects of drinking hydrogen-rich water on 49 patients receiving radiotherapy for malignant liver tumors. Hydrogen-rich water was produced by placing a metallic magnesium stick into drinking water (final hydrogen concentration; 0.55~0.65 mM). The Korean version of the European Organization for Research and Treatment of Cancer's QLQ-C30 instrument was used to evaluate global health status and QOL. The concentration of derivatives of reactive oxidative metabolites and biological antioxidant power in the peripheral blood were assessed. RESULTS: The consumption of hydrogen-rich water for 6 weeks reduced reactive oxygen metabolites in the blood and maintained blood oxidation potential. QOL scores during radiotherapy were significantly improved in patients treated with hydrogen-rich water compared to patients receiving placebo water. There was no difference in tumor response to radiotherapy between the two groups. CONCLUSIONS: Daily consumption of hydrogen-rich water is a potentially novel, therapeutic strategy for improving QOL after radiation exposure. Consumption of hydrogen-rich water reduces the biological reaction to radiation-induced oxidative stress without compromising anti-tumor effects.
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spelling pubmed-32319382011-12-07 Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors Kang, Ki-Mun Kang, Young-Nam Choi, Ihil-Bong Gu, Yeunhwa Kawamura, Tomohiro Toyoda, Yoshiya Nakao, Atsunori Med Gas Res Short Communication BACKGROUND: Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL). Many side effects of radiotherapy are believed to be associated with increased oxidative stress and inflammation due to the generation of reactive oxygen species during radiotherapy. Hydrogen can be administered as a therapeutic medical gas, has antioxidant properties, and reduces inflammation in tissues. This study examined whether hydrogen treatment, in the form of hydrogen-supplemented water, improved QOL in patients receiving radiotherapy. METHODS: A randomized, placebo-controlled study was performed to evaluate the effects of drinking hydrogen-rich water on 49 patients receiving radiotherapy for malignant liver tumors. Hydrogen-rich water was produced by placing a metallic magnesium stick into drinking water (final hydrogen concentration; 0.55~0.65 mM). The Korean version of the European Organization for Research and Treatment of Cancer's QLQ-C30 instrument was used to evaluate global health status and QOL. The concentration of derivatives of reactive oxidative metabolites and biological antioxidant power in the peripheral blood were assessed. RESULTS: The consumption of hydrogen-rich water for 6 weeks reduced reactive oxygen metabolites in the blood and maintained blood oxidation potential. QOL scores during radiotherapy were significantly improved in patients treated with hydrogen-rich water compared to patients receiving placebo water. There was no difference in tumor response to radiotherapy between the two groups. CONCLUSIONS: Daily consumption of hydrogen-rich water is a potentially novel, therapeutic strategy for improving QOL after radiation exposure. Consumption of hydrogen-rich water reduces the biological reaction to radiation-induced oxidative stress without compromising anti-tumor effects. BioMed Central 2011-06-07 /pmc/articles/PMC3231938/ /pubmed/22146004 http://dx.doi.org/10.1186/2045-9912-1-11 Text en Copyright ©2011 Kang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Kang, Ki-Mun
Kang, Young-Nam
Choi, Ihil-Bong
Gu, Yeunhwa
Kawamura, Tomohiro
Toyoda, Yoshiya
Nakao, Atsunori
Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors
title Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors
title_full Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors
title_fullStr Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors
title_full_unstemmed Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors
title_short Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors
title_sort effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231938/
https://www.ncbi.nlm.nih.gov/pubmed/22146004
http://dx.doi.org/10.1186/2045-9912-1-11
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