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Preparation and gamma scintigraphic evaluation of colon specific pellets of ketoprofen prepared by powder layering technology
BACKGROUND AND THE PURPOSE OF THE STUDY: Multiparticulates by powder layering process have advantages of the uniform distribution of the binder solution, easy-to-clean pan and the possibility of applying the successive functional film coating using the same equipment. This study relates to a multipa...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232077/ https://www.ncbi.nlm.nih.gov/pubmed/22615639 |
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author | Subhabrota, M Souvik, R Subhadeep, C |
author_facet | Subhabrota, M Souvik, R Subhadeep, C |
author_sort | Subhabrota, M |
collection | PubMed |
description | BACKGROUND AND THE PURPOSE OF THE STUDY: Multiparticulates by powder layering process have advantages of the uniform distribution of the binder solution, easy-to-clean pan and the possibility of applying the successive functional film coating using the same equipment. This study relates to a multiparticulate formulation comprising pellets with a multilayer of pectin-ethyl cellulose on non pareil seeds by powder layering technology. The pellets were prepared to target ketoprofen in colon based on the microbial enzyme dependent drug release mechanism. METHODS: Multiparticulate formulation by powder layering technology was prepared by conventional pan coating process to evaluate the effect of 59% methoxylated pectin and 45 cps ethyl cellulose on coating label. The formulations were tagged with (99m)Tc-DTPA, a tracer in gamma scintigraphy study to evaluate the transit behavior of drug loaded pellets and compared with uncoated pellets to evaluate its specific release. RESULTS: The transit behavior and scintigraphy image clearly indicates that the formulation can delay the drug release prior to colon. In albino rabbit, the coated pellets released drug in the colon indicating that site specificity has been achieved with pectin/ethyl cellulose coating at 1:2 ratio with 20% coating label. MAJOR CONCLUSION: Formulation containing pectin and ethyl cellulose with suitable coating label may be suitable as a coating formulation for colon delivery of ketoprofen and can be successfully evaluated by gamma scintigraphy method. |
format | Online Article Text |
id | pubmed-3232077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-32320772012-05-21 Preparation and gamma scintigraphic evaluation of colon specific pellets of ketoprofen prepared by powder layering technology Subhabrota, M Souvik, R Subhadeep, C Daru Original Article BACKGROUND AND THE PURPOSE OF THE STUDY: Multiparticulates by powder layering process have advantages of the uniform distribution of the binder solution, easy-to-clean pan and the possibility of applying the successive functional film coating using the same equipment. This study relates to a multiparticulate formulation comprising pellets with a multilayer of pectin-ethyl cellulose on non pareil seeds by powder layering technology. The pellets were prepared to target ketoprofen in colon based on the microbial enzyme dependent drug release mechanism. METHODS: Multiparticulate formulation by powder layering technology was prepared by conventional pan coating process to evaluate the effect of 59% methoxylated pectin and 45 cps ethyl cellulose on coating label. The formulations were tagged with (99m)Tc-DTPA, a tracer in gamma scintigraphy study to evaluate the transit behavior of drug loaded pellets and compared with uncoated pellets to evaluate its specific release. RESULTS: The transit behavior and scintigraphy image clearly indicates that the formulation can delay the drug release prior to colon. In albino rabbit, the coated pellets released drug in the colon indicating that site specificity has been achieved with pectin/ethyl cellulose coating at 1:2 ratio with 20% coating label. MAJOR CONCLUSION: Formulation containing pectin and ethyl cellulose with suitable coating label may be suitable as a coating formulation for colon delivery of ketoprofen and can be successfully evaluated by gamma scintigraphy method. Tehran University of Medical Sciences 2011 /pmc/articles/PMC3232077/ /pubmed/22615639 Text en © 2011 Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Original Article Subhabrota, M Souvik, R Subhadeep, C Preparation and gamma scintigraphic evaluation of colon specific pellets of ketoprofen prepared by powder layering technology |
title | Preparation and gamma scintigraphic evaluation of colon specific pellets of ketoprofen prepared by powder layering technology |
title_full | Preparation and gamma scintigraphic evaluation of colon specific pellets of ketoprofen prepared by powder layering technology |
title_fullStr | Preparation and gamma scintigraphic evaluation of colon specific pellets of ketoprofen prepared by powder layering technology |
title_full_unstemmed | Preparation and gamma scintigraphic evaluation of colon specific pellets of ketoprofen prepared by powder layering technology |
title_short | Preparation and gamma scintigraphic evaluation of colon specific pellets of ketoprofen prepared by powder layering technology |
title_sort | preparation and gamma scintigraphic evaluation of colon specific pellets of ketoprofen prepared by powder layering technology |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232077/ https://www.ncbi.nlm.nih.gov/pubmed/22615639 |
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