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The influence of operational parameters and feed preparation in a convective batch ribbon powder mixer

PURPOSE: To investigate the effect of feed preparation characteristics and operational parameters on mixing homogeneity in a convective batch ribbon mixer. METHODS: Lactose 100M, lactose 200M, ascorbic acid, and zinc oxide powders were used for the mixing study. Operational parameters studied were r...

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Autores principales: Yeow, Sin Tung, Shahar, Asnawi, Aziz, Norashikin Abdul, Anuar, Mohd Shamsul, Yusof, Yus Aniza, Taip, Farah Saleena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232173/
https://www.ncbi.nlm.nih.gov/pubmed/22162640
http://dx.doi.org/10.2147/DDDT.S25047
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author Yeow, Sin Tung
Shahar, Asnawi
Aziz, Norashikin Abdul
Anuar, Mohd Shamsul
Yusof, Yus Aniza
Taip, Farah Saleena
author_facet Yeow, Sin Tung
Shahar, Asnawi
Aziz, Norashikin Abdul
Anuar, Mohd Shamsul
Yusof, Yus Aniza
Taip, Farah Saleena
author_sort Yeow, Sin Tung
collection PubMed
description PURPOSE: To investigate the effect of feed preparation characteristics and operational parameters on mixing homogeneity in a convective batch ribbon mixer. METHODS: Lactose 100M, lactose 200M, ascorbic acid, and zinc oxide powders were used for the mixing study. Operational parameters studied were rotational speed and mixing time. The feed preparations studied were the use of preblending and the particle size of the feed materials. The blends of ascorbic acid, zinc oxide, and lactose were prepared with preblending and without preblending, prior to mixing at different blender rotation speeds and mixing times. Chemical tests were performed to measure the homogeneity of the ascorbic acid in the model mixture. RESULTS: With preblending, a mixture with lactose 200M achieved the required homogeneity in a shorter period of time at a lower rotational speed. CONCLUSION: The results indicated that the homogeneity of the mixtures was influenced by the blender rotation speed and mixing time. Better mixing can be obtained with higher rotation speeds and longer mixing time. It was also observed that preblending and smaller feed particle size achieved the required homogeneity in a shorter period of time at a lower rotational speed. These results illustrate that using binders with a smaller particle size and a preblending technique improves the mixing process in a convective batch ribbon powder mixer. However, prolonged periods of high-speed mixing will lead to mixture segregation.
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spelling pubmed-32321732011-12-08 The influence of operational parameters and feed preparation in a convective batch ribbon powder mixer Yeow, Sin Tung Shahar, Asnawi Aziz, Norashikin Abdul Anuar, Mohd Shamsul Yusof, Yus Aniza Taip, Farah Saleena Drug Des Devel Ther Short Report PURPOSE: To investigate the effect of feed preparation characteristics and operational parameters on mixing homogeneity in a convective batch ribbon mixer. METHODS: Lactose 100M, lactose 200M, ascorbic acid, and zinc oxide powders were used for the mixing study. Operational parameters studied were rotational speed and mixing time. The feed preparations studied were the use of preblending and the particle size of the feed materials. The blends of ascorbic acid, zinc oxide, and lactose were prepared with preblending and without preblending, prior to mixing at different blender rotation speeds and mixing times. Chemical tests were performed to measure the homogeneity of the ascorbic acid in the model mixture. RESULTS: With preblending, a mixture with lactose 200M achieved the required homogeneity in a shorter period of time at a lower rotational speed. CONCLUSION: The results indicated that the homogeneity of the mixtures was influenced by the blender rotation speed and mixing time. Better mixing can be obtained with higher rotation speeds and longer mixing time. It was also observed that preblending and smaller feed particle size achieved the required homogeneity in a shorter period of time at a lower rotational speed. These results illustrate that using binders with a smaller particle size and a preblending technique improves the mixing process in a convective batch ribbon powder mixer. However, prolonged periods of high-speed mixing will lead to mixture segregation. Dove Medical Press 2011-11-14 /pmc/articles/PMC3232173/ /pubmed/22162640 http://dx.doi.org/10.2147/DDDT.S25047 Text en © 2011 Yeow et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Short Report
Yeow, Sin Tung
Shahar, Asnawi
Aziz, Norashikin Abdul
Anuar, Mohd Shamsul
Yusof, Yus Aniza
Taip, Farah Saleena
The influence of operational parameters and feed preparation in a convective batch ribbon powder mixer
title The influence of operational parameters and feed preparation in a convective batch ribbon powder mixer
title_full The influence of operational parameters and feed preparation in a convective batch ribbon powder mixer
title_fullStr The influence of operational parameters and feed preparation in a convective batch ribbon powder mixer
title_full_unstemmed The influence of operational parameters and feed preparation in a convective batch ribbon powder mixer
title_short The influence of operational parameters and feed preparation in a convective batch ribbon powder mixer
title_sort influence of operational parameters and feed preparation in a convective batch ribbon powder mixer
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232173/
https://www.ncbi.nlm.nih.gov/pubmed/22162640
http://dx.doi.org/10.2147/DDDT.S25047
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