Genetic Knockdown and Pharmacological Inhibition of Parasite Multidrug Resistance Transporters Disrupts Egg Production in Schistosoma mansoni

P-glycoprotein (Pgp) and multidrug resistance-associated proteins (MRPs) are ATP-dependent transporters involved in efflux of toxins and xenobiotics from cells. When overexpressed, these transporters can mediate multidrug resistance (MDR) in mammalian cells, and changes in Pgp expression and sequenc...

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Detalles Bibliográficos
Autores principales: Kasinathan, Ravi S., Morgan, William M., Greenberg, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232217/
https://www.ncbi.nlm.nih.gov/pubmed/22163059
http://dx.doi.org/10.1371/journal.pntd.0001425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232217/
https://www.ncbi.nlm.nih.gov/pubmed/22163059
http://dx.doi.org/10.1371/journal.pntd.0001425

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