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Targeted treatment for chronic lymphocytic leukemia

The treatment of chronic lymphocytic leukemia (CLL) has evolved over the last few decades. Recognition has increased of several key components of CLL biology currently manipulated for therapeutics. A milestone in the treatment of CLL was reached with the incorporation of immunotherapy with conventio...

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Detalles Bibliográficos
Autores principales: Masood, Aisha, Sher, Taimur, Paulus, Aneel, Miller, Kena C, Chitta, Kasyapa S, Chanan-Khan, Asher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233276/
https://www.ncbi.nlm.nih.gov/pubmed/22162923
http://dx.doi.org/10.2147/OTT.S7173
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author Masood, Aisha
Sher, Taimur
Paulus, Aneel
Miller, Kena C
Chitta, Kasyapa S
Chanan-Khan, Asher
author_facet Masood, Aisha
Sher, Taimur
Paulus, Aneel
Miller, Kena C
Chitta, Kasyapa S
Chanan-Khan, Asher
author_sort Masood, Aisha
collection PubMed
description The treatment of chronic lymphocytic leukemia (CLL) has evolved over the last few decades. Recognition has increased of several key components of CLL biology currently manipulated for therapeutics. A milestone in the treatment of CLL was reached with the incorporation of immunotherapy with conventional chemotherapy. The fludarabine/cyclophosphamide/rituximab combination has demonstrated survival advantage for the first time in the treatment of CLL. Several other biological compounds are being explored with the hope of improving responses, impacting survival, and ultimately curing CLL. Important agents being tested are targeted on CLL surface molecules and their ligands, signal transduction protein and oncogenes. This review provides a brief summary of the recent advances made in preclinical and clinical investigation of selected promising therapeutic agents, which lead the target-directed therapeutic approach.
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spelling pubmed-32332762011-12-09 Targeted treatment for chronic lymphocytic leukemia Masood, Aisha Sher, Taimur Paulus, Aneel Miller, Kena C Chitta, Kasyapa S Chanan-Khan, Asher Onco Targets Ther Review The treatment of chronic lymphocytic leukemia (CLL) has evolved over the last few decades. Recognition has increased of several key components of CLL biology currently manipulated for therapeutics. A milestone in the treatment of CLL was reached with the incorporation of immunotherapy with conventional chemotherapy. The fludarabine/cyclophosphamide/rituximab combination has demonstrated survival advantage for the first time in the treatment of CLL. Several other biological compounds are being explored with the hope of improving responses, impacting survival, and ultimately curing CLL. Important agents being tested are targeted on CLL surface molecules and their ligands, signal transduction protein and oncogenes. This review provides a brief summary of the recent advances made in preclinical and clinical investigation of selected promising therapeutic agents, which lead the target-directed therapeutic approach. Dove Medical Press 2011-11-04 /pmc/articles/PMC3233276/ /pubmed/22162923 http://dx.doi.org/10.2147/OTT.S7173 Text en © 2011 Masood et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Masood, Aisha
Sher, Taimur
Paulus, Aneel
Miller, Kena C
Chitta, Kasyapa S
Chanan-Khan, Asher
Targeted treatment for chronic lymphocytic leukemia
title Targeted treatment for chronic lymphocytic leukemia
title_full Targeted treatment for chronic lymphocytic leukemia
title_fullStr Targeted treatment for chronic lymphocytic leukemia
title_full_unstemmed Targeted treatment for chronic lymphocytic leukemia
title_short Targeted treatment for chronic lymphocytic leukemia
title_sort targeted treatment for chronic lymphocytic leukemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233276/
https://www.ncbi.nlm.nih.gov/pubmed/22162923
http://dx.doi.org/10.2147/OTT.S7173
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