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Antiproliferative Effect of Aaptamine on Human Chronic Myeloid Leukemia K562 Cells

We previously isolated aaptamine, a benzonaphthyridine alkaloid, from marine sponge Aaptos suberitoids. In this study, we investigated the anti-proliferative effect of aaptamine on chronic myeloid leukemia (CML) K562 cells. Aaptamine inhibited growth of K562 with a GI50 as 10 μM, and arrested cell c...

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Detalles Bibliográficos
Autores principales:	Jin, Meihua, Zhao, Wennan, Zhang, Yanwen, Kobayashi, Motomasa, Duan, Hongquan, Kong, Dexin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233409/ https://www.ncbi.nlm.nih.gov/pubmed/22174603 http://dx.doi.org/10.3390/ijms12117352

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