Solubility Enhancement of Steviol Glycosides and Characterization of Their Inclusion Complexes with Gamma-Cyclodextrin

Steviol glycosidesrebaudioside (reb) A, C and D have low aqueous solubilities. To improve their aqueous solubilities, inclusion complex of steviol glycosides, reb A, C and D and gamma cyclodextrin were prepared by freeze drying method and further characterized by means of differential scanning calor...

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Detalles Bibliográficos
Autores principales: Upreti, Mani, Strassburger, Ken, Chen, You L., Wu, Shaoxiong, Prakash, Indra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233421/
https://www.ncbi.nlm.nih.gov/pubmed/22174615
http://dx.doi.org/10.3390/ijms12117529
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author Upreti, Mani
Strassburger, Ken
Chen, You L.
Wu, Shaoxiong
Prakash, Indra
author_facet Upreti, Mani
Strassburger, Ken
Chen, You L.
Wu, Shaoxiong
Prakash, Indra
author_sort Upreti, Mani
collection PubMed
description Steviol glycosidesrebaudioside (reb) A, C and D have low aqueous solubilities. To improve their aqueous solubilities, inclusion complex of steviol glycosides, reb A, C and D and gamma cyclodextrin were prepared by freeze drying method and further characterized by means of differential scanning calorimetry, Fourier transform infrared spectroscopy and Raman spectroscopy. The effect of gamma cyclodextrin on chemical shifts of the steviol glycosides was also studied in proton NMR experiments as well as in solid state (13)C CP/MAS NMR experiments. These results indicated that the steviol glycosides were clearly in inclusion complex formation with the gamma cyclodextrin which also results in solubility enhancement of these steviol glycosides. Phase solubility studies showed that amounts of soluble reb A, C and D increased with increasing amounts of gamma cyclodextrin indicating formation of 1:1 stoichiometric and higher order inclusion complexes.
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spelling pubmed-32334212011-12-15 Solubility Enhancement of Steviol Glycosides and Characterization of Their Inclusion Complexes with Gamma-Cyclodextrin Upreti, Mani Strassburger, Ken Chen, You L. Wu, Shaoxiong Prakash, Indra Int J Mol Sci Article Steviol glycosidesrebaudioside (reb) A, C and D have low aqueous solubilities. To improve their aqueous solubilities, inclusion complex of steviol glycosides, reb A, C and D and gamma cyclodextrin were prepared by freeze drying method and further characterized by means of differential scanning calorimetry, Fourier transform infrared spectroscopy and Raman spectroscopy. The effect of gamma cyclodextrin on chemical shifts of the steviol glycosides was also studied in proton NMR experiments as well as in solid state (13)C CP/MAS NMR experiments. These results indicated that the steviol glycosides were clearly in inclusion complex formation with the gamma cyclodextrin which also results in solubility enhancement of these steviol glycosides. Phase solubility studies showed that amounts of soluble reb A, C and D increased with increasing amounts of gamma cyclodextrin indicating formation of 1:1 stoichiometric and higher order inclusion complexes. Molecular Diversity Preservation International (MDPI) 2011-11-03 /pmc/articles/PMC3233421/ /pubmed/22174615 http://dx.doi.org/10.3390/ijms12117529 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Upreti, Mani
Strassburger, Ken
Chen, You L.
Wu, Shaoxiong
Prakash, Indra
Solubility Enhancement of Steviol Glycosides and Characterization of Their Inclusion Complexes with Gamma-Cyclodextrin
title Solubility Enhancement of Steviol Glycosides and Characterization of Their Inclusion Complexes with Gamma-Cyclodextrin
title_full Solubility Enhancement of Steviol Glycosides and Characterization of Their Inclusion Complexes with Gamma-Cyclodextrin
title_fullStr Solubility Enhancement of Steviol Glycosides and Characterization of Their Inclusion Complexes with Gamma-Cyclodextrin
title_full_unstemmed Solubility Enhancement of Steviol Glycosides and Characterization of Their Inclusion Complexes with Gamma-Cyclodextrin
title_short Solubility Enhancement of Steviol Glycosides and Characterization of Their Inclusion Complexes with Gamma-Cyclodextrin
title_sort solubility enhancement of steviol glycosides and characterization of their inclusion complexes with gamma-cyclodextrin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233421/
https://www.ncbi.nlm.nih.gov/pubmed/22174615
http://dx.doi.org/10.3390/ijms12117529
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