In Silico Identification of Structure Requirement for Novel Thiazole and Oxazole Derivatives as Potent Fructose 1,6-Bisphosphatase Inhibitors

Fructose 1,6-bisphosphatase (FBPase) has been identified as a drug discovery target for lowering glucose in type 2 diabetes mellitus. In this study, a large series of 105 FBPase inhibitors were studied using a combinational method by 3D-QSAR, molecular docking and molecular dynamics simulations for...

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Detalles Bibliográficos
Autores principales: Hao, Ming, Zhang, Xiaole, Ren, Hong, Li, Yan, Zhang, Shuwei, Luo, Fang, Ji, Mingjuan, Li, Guohui, Yang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233463/
https://www.ncbi.nlm.nih.gov/pubmed/22174657
http://dx.doi.org/10.3390/ijms12118161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233463/
https://www.ncbi.nlm.nih.gov/pubmed/22174657
http://dx.doi.org/10.3390/ijms12118161

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