Onset and Progression of Behavioral and Molecular Phenotypes in a Novel Congenic R6/2 Line Exhibiting Intergenerational CAG Repeat Stability

In the present study we report on the use of speed congenics to generate a C57BL/6J congenic line of HD-model R6/2 mice carrying 110 CAG repeats, which uniquely exhibits minimal intergenerational instability. We also report the first identification of the R6/2 transgene insertion site. The relativel...

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Detalles Bibliográficos
Autores principales: Cowin, Randi-Michelle, Bui, Nghiem, Graham, Deanna, Green, Jennie R., Grueninger, Stephan, Yuva-Paylor, Lisa A., Syed, Arsalan U., Weiss, Andreas, Paylor, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233565/
https://www.ncbi.nlm.nih.gov/pubmed/22163300
http://dx.doi.org/10.1371/journal.pone.0028409

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