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Two-Way Minimization: A Novel Treatment Allocation Method for Small Trials
Randomization is a hallmark of clinical trials. If a trial entails very few subjects and has many prognostic factors (or many factor levels) to be balanced, minimization is a more efficient method to achieve balance than a simple randomization. We propose a novel minimization method, the ‘two-way mi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233579/ https://www.ncbi.nlm.nih.gov/pubmed/22163317 http://dx.doi.org/10.1371/journal.pone.0028604 |