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PTEN breast cancer susceptibility: a matter of dose
The phosphatase and tensin homolog located on chromosome ten, PTEN, is one of the most commonly mutated tumor suppressor genes (TSGs) in human cancer [1–3]. PTEN catalyzes the conversion of the membrane lipid second messenger PIP3 to PIP2 and is therefore a key mediator of the AKT/PKB pathway [4,5]....
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cancer Intelligence
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234025/ https://www.ncbi.nlm.nih.gov/pubmed/22276040 http://dx.doi.org/10.3332/ecancer.2010.192 |