Cancer stem cells in melanoma

The identification of cancer stem cells in various malignancies led to the hypothesis that these cells have the exclusive ability of self-renewal, contribute to the plasticity of the tumours and may be the cause for ineffective cancer therapies. Several markers of melanoma stem cells have been descr...

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Autores principales: Regenbrecht, C, Welte, Y, Hugel, R, Trefzer, U, Losch, FO, Adjaye, J, Walden, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2008
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234043/
https://www.ncbi.nlm.nih.gov/pubmed/22275987
http://dx.doi.org/10.3332/ecancer.2008.114
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author Regenbrecht, C
Welte, Y
Hugel, R
Trefzer, U
Losch, FO
Adjaye, J
Walden, P
author_facet Regenbrecht, C
Welte, Y
Hugel, R
Trefzer, U
Losch, FO
Adjaye, J
Walden, P
author_sort Regenbrecht, C
collection PubMed
description The identification of cancer stem cells in various malignancies led to the hypothesis that these cells have the exclusive ability of self-renewal, contribute to the plasticity of the tumours and may be the cause for ineffective cancer therapies. Several markers of melanoma stem cells have been described in recent studies including CD133, CD166, Nestin and BMI-1. Further studies are necessary to identify, better define and understand the origin and function of cancer stem cells. If confirmed that cancer stem cells play an important role in malignancy, therapeutic strategies may need to be redirected towards these cells to circumvent the failure of conventional therapies.
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spelling pubmed-32340432012-01-24 Cancer stem cells in melanoma Regenbrecht, C Welte, Y Hugel, R Trefzer, U Losch, FO Adjaye, J Walden, P Ecancermedicalscience Short Communications The identification of cancer stem cells in various malignancies led to the hypothesis that these cells have the exclusive ability of self-renewal, contribute to the plasticity of the tumours and may be the cause for ineffective cancer therapies. Several markers of melanoma stem cells have been described in recent studies including CD133, CD166, Nestin and BMI-1. Further studies are necessary to identify, better define and understand the origin and function of cancer stem cells. If confirmed that cancer stem cells play an important role in malignancy, therapeutic strategies may need to be redirected towards these cells to circumvent the failure of conventional therapies. Cancer Intelligence 2008-12-01 /pmc/articles/PMC3234043/ /pubmed/22275987 http://dx.doi.org/10.3332/ecancer.2008.114 Text en Copyright: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Regenbrecht, C
Welte, Y
Hugel, R
Trefzer, U
Losch, FO
Adjaye, J
Walden, P
Cancer stem cells in melanoma
title Cancer stem cells in melanoma
title_full Cancer stem cells in melanoma
title_fullStr Cancer stem cells in melanoma
title_full_unstemmed Cancer stem cells in melanoma
title_short Cancer stem cells in melanoma
title_sort cancer stem cells in melanoma
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234043/
https://www.ncbi.nlm.nih.gov/pubmed/22275987
http://dx.doi.org/10.3332/ecancer.2008.114
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