Syzygium cumini inhibits growth and induces apoptosis in cervical cancer cell lines: a primary study

Cervical cancer is common among women in the Indian subcontinent and the incidences and death rates are gradually increasing over the years. Several dietary phytochemicals have been reported to have growth inhibitory and apoptotic effect on HeLa and other cervical cell lines. In this study, using Ho...

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Autores principales: Barh, D, Viswanathan, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234045/
https://www.ncbi.nlm.nih.gov/pubmed/22275971
http://dx.doi.org/10.3332/ecancer.2008.83
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author Barh, D
Viswanathan, G
author_facet Barh, D
Viswanathan, G
author_sort Barh, D
collection PubMed
description Cervical cancer is common among women in the Indian subcontinent and the incidences and death rates are gradually increasing over the years. Several dietary phytochemicals have been reported to have growth inhibitory and apoptotic effect on HeLa and other cervical cell lines. In this study, using Hoechst 33342 staining, MTT, Annexin V-FLUOS/PI and TUNEL assays we demonstrated that Syzygium cumini extract inhibits the growth and induces apoptosis in HeLa and SiHa cervical cancer cell lines in a dose- and time-dependent manner. The phytochemical, its mode of action and safety issues are yet to be determined.
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spelling pubmed-32340452012-01-24 Syzygium cumini inhibits growth and induces apoptosis in cervical cancer cell lines: a primary study Barh, D Viswanathan, G Ecancermedicalscience Research Article Cervical cancer is common among women in the Indian subcontinent and the incidences and death rates are gradually increasing over the years. Several dietary phytochemicals have been reported to have growth inhibitory and apoptotic effect on HeLa and other cervical cell lines. In this study, using Hoechst 33342 staining, MTT, Annexin V-FLUOS/PI and TUNEL assays we demonstrated that Syzygium cumini extract inhibits the growth and induces apoptosis in HeLa and SiHa cervical cancer cell lines in a dose- and time-dependent manner. The phytochemical, its mode of action and safety issues are yet to be determined. Cancer Intelligence 2008-08-21 /pmc/articles/PMC3234045/ /pubmed/22275971 http://dx.doi.org/10.3332/ecancer.2008.83 Text en Copyright: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Barh, D
Viswanathan, G
Syzygium cumini inhibits growth and induces apoptosis in cervical cancer cell lines: a primary study
title Syzygium cumini inhibits growth and induces apoptosis in cervical cancer cell lines: a primary study
title_full Syzygium cumini inhibits growth and induces apoptosis in cervical cancer cell lines: a primary study
title_fullStr Syzygium cumini inhibits growth and induces apoptosis in cervical cancer cell lines: a primary study
title_full_unstemmed Syzygium cumini inhibits growth and induces apoptosis in cervical cancer cell lines: a primary study
title_short Syzygium cumini inhibits growth and induces apoptosis in cervical cancer cell lines: a primary study
title_sort syzygium cumini inhibits growth and induces apoptosis in cervical cancer cell lines: a primary study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234045/
https://www.ncbi.nlm.nih.gov/pubmed/22275971
http://dx.doi.org/10.3332/ecancer.2008.83
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