Cargando…

Epidemiological Impact of Mandatory Vaccination against Hepatitis B in Italian Young Adults

BACKGROUND: Viral hepatitis caused by hepatitis B virus (HBV) is a leading cause of acute and chronic liver diseases worldwide. OBJECTIVES: In Italy, a mandatory vaccination policy was introduced in 1991 and was established for all newborns and 12-year-old individuals. In 2004, vaccination of 12-yea...

Descripción completa

Detalles Bibliográficos
Autores principales: Campagna, Marcello, Siddu, Andrea, Meloni, Angelo, Murru, Claudia, Masia, Giuseppina, Coppola, Rosa Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234542/
https://www.ncbi.nlm.nih.gov/pubmed/22235220
http://dx.doi.org/10.5812/kowsar.1735143X.723
_version_ 1782218521131876352
author Campagna, Marcello
Siddu, Andrea
Meloni, Angelo
Murru, Claudia
Masia, Giuseppina
Coppola, Rosa Cristina
author_facet Campagna, Marcello
Siddu, Andrea
Meloni, Angelo
Murru, Claudia
Masia, Giuseppina
Coppola, Rosa Cristina
author_sort Campagna, Marcello
collection PubMed
description BACKGROUND: Viral hepatitis caused by hepatitis B virus (HBV) is a leading cause of acute and chronic liver diseases worldwide. OBJECTIVES: In Italy, a mandatory vaccination policy was introduced in 1991 and was established for all newborns and 12-year-old individuals. In 2004, vaccination of 12-yearold adolescents was discontinued, and that of infants was maintained. PATIENTS AND METHODS: We evaluated the seroprevalence of HBV markers in 806 individuals, who were vaccinated at birth or at 12 years of age, to assess the effectiveness of the national policy against HBV. RESULTS: The overall prevalence of anti-HBs antibodies was 90.32% (95% confidence interval [CI]: 88.28–92.36%); 2.23% (95% CI: 1.21–3.25%) of the subjects were positive for both antibodies to HBsAg (anti-HBs) and antibodies to hepatitis B core antigen (anti-HBc), whereas 5.83% (95% CI 4.21–7.45) of the subjects were negative for all markers tested. Further, 1.61% (95% CI: 0.74–2.48%) of the subjects were positive for hepatitis B surface antigen (HBsAg). CONCLUSIONS: Our data provide additional evidence that HBV vaccination can confer long-term immunity when performed at birth and when performed for healthy adolescents; moreover, the results show the effectiveness of the application of a national vaccination strategy.
format Online
Article
Text
id pubmed-3234542
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Kowsar
record_format MEDLINE/PubMed
spelling pubmed-32345422012-01-10 Epidemiological Impact of Mandatory Vaccination against Hepatitis B in Italian Young Adults Campagna, Marcello Siddu, Andrea Meloni, Angelo Murru, Claudia Masia, Giuseppina Coppola, Rosa Cristina Hepat Mon Brief Report BACKGROUND: Viral hepatitis caused by hepatitis B virus (HBV) is a leading cause of acute and chronic liver diseases worldwide. OBJECTIVES: In Italy, a mandatory vaccination policy was introduced in 1991 and was established for all newborns and 12-year-old individuals. In 2004, vaccination of 12-yearold adolescents was discontinued, and that of infants was maintained. PATIENTS AND METHODS: We evaluated the seroprevalence of HBV markers in 806 individuals, who were vaccinated at birth or at 12 years of age, to assess the effectiveness of the national policy against HBV. RESULTS: The overall prevalence of anti-HBs antibodies was 90.32% (95% confidence interval [CI]: 88.28–92.36%); 2.23% (95% CI: 1.21–3.25%) of the subjects were positive for both antibodies to HBsAg (anti-HBs) and antibodies to hepatitis B core antigen (anti-HBc), whereas 5.83% (95% CI 4.21–7.45) of the subjects were negative for all markers tested. Further, 1.61% (95% CI: 0.74–2.48%) of the subjects were positive for hepatitis B surface antigen (HBsAg). CONCLUSIONS: Our data provide additional evidence that HBV vaccination can confer long-term immunity when performed at birth and when performed for healthy adolescents; moreover, the results show the effectiveness of the application of a national vaccination strategy. Kowsar 2011-09-01 2011-09-01 /pmc/articles/PMC3234542/ /pubmed/22235220 http://dx.doi.org/10.5812/kowsar.1735143X.723 Text en Copyright © 2011, Kowsar M.P. Co. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Campagna, Marcello
Siddu, Andrea
Meloni, Angelo
Murru, Claudia
Masia, Giuseppina
Coppola, Rosa Cristina
Epidemiological Impact of Mandatory Vaccination against Hepatitis B in Italian Young Adults
title Epidemiological Impact of Mandatory Vaccination against Hepatitis B in Italian Young Adults
title_full Epidemiological Impact of Mandatory Vaccination against Hepatitis B in Italian Young Adults
title_fullStr Epidemiological Impact of Mandatory Vaccination against Hepatitis B in Italian Young Adults
title_full_unstemmed Epidemiological Impact of Mandatory Vaccination against Hepatitis B in Italian Young Adults
title_short Epidemiological Impact of Mandatory Vaccination against Hepatitis B in Italian Young Adults
title_sort epidemiological impact of mandatory vaccination against hepatitis b in italian young adults
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234542/
https://www.ncbi.nlm.nih.gov/pubmed/22235220
http://dx.doi.org/10.5812/kowsar.1735143X.723
work_keys_str_mv AT campagnamarcello epidemiologicalimpactofmandatoryvaccinationagainsthepatitisbinitalianyoungadults
AT sidduandrea epidemiologicalimpactofmandatoryvaccinationagainsthepatitisbinitalianyoungadults
AT meloniangelo epidemiologicalimpactofmandatoryvaccinationagainsthepatitisbinitalianyoungadults
AT murruclaudia epidemiologicalimpactofmandatoryvaccinationagainsthepatitisbinitalianyoungadults
AT masiagiuseppina epidemiologicalimpactofmandatoryvaccinationagainsthepatitisbinitalianyoungadults
AT coppolarosacristina epidemiologicalimpactofmandatoryvaccinationagainsthepatitisbinitalianyoungadults