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A Rhabdomyosarcoma Arising in the Larynx of a Dog
A neoplastic nodular lesion, 2 × 3 cm in diameter, was found in the larynx of a 6-year-old spayed female dog. The tumor was ill-circumscribed, consisting histologically of large round cells with abundant cytoplasm interspersed with small round cells with less cytoplasm and occasional multinucleated...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japanese Society of Toxicologic Pathology
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234595/ https://www.ncbi.nlm.nih.gov/pubmed/22272059 http://dx.doi.org/10.1293/tox.24.179 |
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author | Yamate, Jyoji Murai, Fumi Izawa, Takeshi Akiyoshi, Hideo Shimizu, Junichiro Ohashi, Fumihito Kuwamura, Mitsuru |
author_facet | Yamate, Jyoji Murai, Fumi Izawa, Takeshi Akiyoshi, Hideo Shimizu, Junichiro Ohashi, Fumihito Kuwamura, Mitsuru |
author_sort | Yamate, Jyoji |
collection | PubMed |
description | A neoplastic nodular lesion, 2 × 3 cm in diameter, was found in the larynx of a 6-year-old spayed female dog. The tumor was ill-circumscribed, consisting histologically of large round cells with abundant cytoplasm interspersed with small round cells with less cytoplasm and occasional multinucleated cells (myotubes). Immunohistochemically, tumor cells were positive for myoglobin, desmin and vimentin in varying degrees, but negative for S-100 protein, GFAP or cytokeratin. Cytoplasmic myofilaments/myofibrils with a dense Z-line-like structure were seen, the fine structures of which were complemented by PTAH stain. Based on these findings, the tumor was diagnosed as a rhabdomyosarcoma, a very rare tumor in the larynx of dogs. |
format | Online Article Text |
id | pubmed-3234595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Japanese Society of Toxicologic Pathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-32345952012-01-23 A Rhabdomyosarcoma Arising in the Larynx of a Dog Yamate, Jyoji Murai, Fumi Izawa, Takeshi Akiyoshi, Hideo Shimizu, Junichiro Ohashi, Fumihito Kuwamura, Mitsuru J Toxicol Pathol Case Report A neoplastic nodular lesion, 2 × 3 cm in diameter, was found in the larynx of a 6-year-old spayed female dog. The tumor was ill-circumscribed, consisting histologically of large round cells with abundant cytoplasm interspersed with small round cells with less cytoplasm and occasional multinucleated cells (myotubes). Immunohistochemically, tumor cells were positive for myoglobin, desmin and vimentin in varying degrees, but negative for S-100 protein, GFAP or cytokeratin. Cytoplasmic myofilaments/myofibrils with a dense Z-line-like structure were seen, the fine structures of which were complemented by PTAH stain. Based on these findings, the tumor was diagnosed as a rhabdomyosarcoma, a very rare tumor in the larynx of dogs. The Japanese Society of Toxicologic Pathology 2011-10-12 2011-09 /pmc/articles/PMC3234595/ /pubmed/22272059 http://dx.doi.org/10.1293/tox.24.179 Text en ©2011 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Case Report Yamate, Jyoji Murai, Fumi Izawa, Takeshi Akiyoshi, Hideo Shimizu, Junichiro Ohashi, Fumihito Kuwamura, Mitsuru A Rhabdomyosarcoma Arising in the Larynx of a Dog |
title | A Rhabdomyosarcoma Arising in the Larynx of a Dog |
title_full | A Rhabdomyosarcoma Arising in the Larynx of a Dog |
title_fullStr | A Rhabdomyosarcoma Arising in the Larynx of a Dog |
title_full_unstemmed | A Rhabdomyosarcoma Arising in the Larynx of a Dog |
title_short | A Rhabdomyosarcoma Arising in the Larynx of a Dog |
title_sort | rhabdomyosarcoma arising in the larynx of a dog |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234595/ https://www.ncbi.nlm.nih.gov/pubmed/22272059 http://dx.doi.org/10.1293/tox.24.179 |
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