Thyroid Dysplasia in Wistar Hannover GALAS Rats

Thyroid dysplasia was recognized in WistarHan GALAS rats and confirmed as a heritable congenital disorder. The gene or genes involved were not identified, but homozygous animals with thyroid dysplasia also exhibited stunted growth, had reduced pituitary gland growth hormone (GH) and were hypothyroid...

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Detalles Bibliográficos
Autores principales: Weber, Klaus, Ernst, Rainer, Fankhauser, Heinz, Hardisty, Jerry F., Heider, Wolfram, Stevens, Karla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Toxicologic Pathology 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234603/
https://www.ncbi.nlm.nih.gov/pubmed/22271999
http://dx.doi.org/10.1293/tox.22.247
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author Weber, Klaus
Ernst, Rainer
Fankhauser, Heinz
Hardisty, Jerry F.
Heider, Wolfram
Stevens, Karla
author_facet Weber, Klaus
Ernst, Rainer
Fankhauser, Heinz
Hardisty, Jerry F.
Heider, Wolfram
Stevens, Karla
author_sort Weber, Klaus
collection PubMed
description Thyroid dysplasia was recognized in WistarHan GALAS rats and confirmed as a heritable congenital disorder. The gene or genes involved were not identified, but homozygous animals with thyroid dysplasia also exhibited stunted growth, had reduced pituitary gland growth hormone (GH) and were hypothyroid. Heterozygous animals exhibited thyroid dysplasia with normal thyroid hormonal homeostasis and no difference in the incidence of preneoplastic or neoplastic lesions in oncogenicity studies.
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spelling pubmed-32346032012-01-23 Thyroid Dysplasia in Wistar Hannover GALAS Rats Weber, Klaus Ernst, Rainer Fankhauser, Heinz Hardisty, Jerry F. Heider, Wolfram Stevens, Karla J Toxicol Pathol Review Thyroid dysplasia was recognized in WistarHan GALAS rats and confirmed as a heritable congenital disorder. The gene or genes involved were not identified, but homozygous animals with thyroid dysplasia also exhibited stunted growth, had reduced pituitary gland growth hormone (GH) and were hypothyroid. Heterozygous animals exhibited thyroid dysplasia with normal thyroid hormonal homeostasis and no difference in the incidence of preneoplastic or neoplastic lesions in oncogenicity studies. The Japanese Society of Toxicologic Pathology 2009-12 2009-12-21 /pmc/articles/PMC3234603/ /pubmed/22271999 http://dx.doi.org/10.1293/tox.22.247 Text en 2009 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Review
Weber, Klaus
Ernst, Rainer
Fankhauser, Heinz
Hardisty, Jerry F.
Heider, Wolfram
Stevens, Karla
Thyroid Dysplasia in Wistar Hannover GALAS Rats
title Thyroid Dysplasia in Wistar Hannover GALAS Rats
title_full Thyroid Dysplasia in Wistar Hannover GALAS Rats
title_fullStr Thyroid Dysplasia in Wistar Hannover GALAS Rats
title_full_unstemmed Thyroid Dysplasia in Wistar Hannover GALAS Rats
title_short Thyroid Dysplasia in Wistar Hannover GALAS Rats
title_sort thyroid dysplasia in wistar hannover galas rats
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234603/
https://www.ncbi.nlm.nih.gov/pubmed/22271999
http://dx.doi.org/10.1293/tox.22.247
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