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Expression of Vascular Endothelial Growth Factor (VEGF) Associated with Histopathological Changes in Rodent Models of Osteoarthritis
Vascular endothelial growth factor (VEGF) and its receptors have recently reported to be expressed in human osteoarthritis (OA), suggesting that VEGF could be implicated in the pathogenesis of this disease. In the present study, expression of VEGF in the articular cartilage was determined in three d...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Toxicologic Pathology
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234605/ https://www.ncbi.nlm.nih.gov/pubmed/22272053 http://dx.doi.org/10.1293/tox.24.137 |
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author | Yamairi, Fumiko Utsumi, Hiroyuki Ono, Yuuichi Komorita, Naruyasu Tanaka, Masaharu Fukunari, Atsushi |
author_facet | Yamairi, Fumiko Utsumi, Hiroyuki Ono, Yuuichi Komorita, Naruyasu Tanaka, Masaharu Fukunari, Atsushi |
author_sort | Yamairi, Fumiko |
collection | PubMed |
description | Vascular endothelial growth factor (VEGF) and its receptors have recently reported to be expressed in human osteoarthritis (OA), suggesting that VEGF could be implicated in the pathogenesis of this disease. In the present study, expression of VEGF in the articular cartilage was determined in three different OA models: medial meniscectomy and monoiodoacetate (MIA) injection in rats and age-associated spontaneous joint cartilage destruction in guinea pigs. VEGF was detected by immunohistochemical analysis in the regenerative and hypertrophic chondrocytes, perichondrium and osteophyte areas and chondrocyte clones. Stain intensity of VEGF immunoreactivity increased simultaneously with the degree of cartilage destruction and reparation. These results suggest that VEGF is a key factor in the articular cartilage in human OA and animal OA models. |
format | Online Article Text |
id | pubmed-3234605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Japanese Society of Toxicologic Pathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-32346052012-01-23 Expression of Vascular Endothelial Growth Factor (VEGF) Associated with Histopathological Changes in Rodent Models of Osteoarthritis Yamairi, Fumiko Utsumi, Hiroyuki Ono, Yuuichi Komorita, Naruyasu Tanaka, Masaharu Fukunari, Atsushi J Toxicol Pathol Short Communication Vascular endothelial growth factor (VEGF) and its receptors have recently reported to be expressed in human osteoarthritis (OA), suggesting that VEGF could be implicated in the pathogenesis of this disease. In the present study, expression of VEGF in the articular cartilage was determined in three different OA models: medial meniscectomy and monoiodoacetate (MIA) injection in rats and age-associated spontaneous joint cartilage destruction in guinea pigs. VEGF was detected by immunohistochemical analysis in the regenerative and hypertrophic chondrocytes, perichondrium and osteophyte areas and chondrocyte clones. Stain intensity of VEGF immunoreactivity increased simultaneously with the degree of cartilage destruction and reparation. These results suggest that VEGF is a key factor in the articular cartilage in human OA and animal OA models. The Japanese Society of Toxicologic Pathology 2011-06-30 2011-06 /pmc/articles/PMC3234605/ /pubmed/22272053 http://dx.doi.org/10.1293/tox.24.137 Text en ©2011 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Short Communication Yamairi, Fumiko Utsumi, Hiroyuki Ono, Yuuichi Komorita, Naruyasu Tanaka, Masaharu Fukunari, Atsushi Expression of Vascular Endothelial Growth Factor (VEGF) Associated with Histopathological Changes in Rodent Models of Osteoarthritis |
title | Expression of Vascular Endothelial Growth Factor (VEGF) Associated with
Histopathological Changes in Rodent Models of Osteoarthritis |
title_full | Expression of Vascular Endothelial Growth Factor (VEGF) Associated with
Histopathological Changes in Rodent Models of Osteoarthritis |
title_fullStr | Expression of Vascular Endothelial Growth Factor (VEGF) Associated with
Histopathological Changes in Rodent Models of Osteoarthritis |
title_full_unstemmed | Expression of Vascular Endothelial Growth Factor (VEGF) Associated with
Histopathological Changes in Rodent Models of Osteoarthritis |
title_short | Expression of Vascular Endothelial Growth Factor (VEGF) Associated with
Histopathological Changes in Rodent Models of Osteoarthritis |
title_sort | expression of vascular endothelial growth factor (vegf) associated with
histopathological changes in rodent models of osteoarthritis |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234605/ https://www.ncbi.nlm.nih.gov/pubmed/22272053 http://dx.doi.org/10.1293/tox.24.137 |
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