Promoting Effects of Streptozotocin-induced Diabetes on Induction of Hepatic Preneoplastic Lesions by Diethylnitrosamine in Rats

The effects of streptozotocin (STZ)-induced diabetes on induction of hepatic preneoplastic lesions by diethylnitrosamine (DEN) were investigated in male Fischer rats. A single dose of STZ was injected intravenously either 2 weeks before or after initiation with DEN. The blood glucose levels were sig...

Descripción completa

Detalles Bibliográficos
Autores principales: Ichikawa, Kazuhito, Tagawa, Yoshiaki, Kawai, Masaomi, Asamoto, Makoto, Shirai, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Toxicologic Pathology 2010
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234616/
https://www.ncbi.nlm.nih.gov/pubmed/22272023
http://dx.doi.org/10.1293/tox.23.125
_version_ 1782218531271606272
author Ichikawa, Kazuhito
Tagawa, Yoshiaki
Kawai, Masaomi
Asamoto, Makoto
Shirai, Tomoyuki
author_facet Ichikawa, Kazuhito
Tagawa, Yoshiaki
Kawai, Masaomi
Asamoto, Makoto
Shirai, Tomoyuki
author_sort Ichikawa, Kazuhito
collection PubMed
description The effects of streptozotocin (STZ)-induced diabetes on induction of hepatic preneoplastic lesions by diethylnitrosamine (DEN) were investigated in male Fischer rats. A single dose of STZ was injected intravenously either 2 weeks before or after initiation with DEN. The blood glucose levels were significantly elevated from 1 week after STZ-injection until autopsy. The numbers of GST-P positive foci at 1 week after DEN administration in the STZ-injected rats were similar to those in the non-diabetic rats. In contrast, both the numbers and areas of GST-P positive foci > 2 mm in diameter 8 weeks after DEN administration were increased significantly in the rats treated with STZ after DEN exposure compared with the non-diabetic control rats. The results suggest that hepatic preneoplastic lesions initiated with DEN are promoted by STZ treatment-inducing diabetes.
format Online
Article
Text
id pubmed-3234616
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher The Japanese Society of Toxicologic Pathology
record_format MEDLINE/PubMed
spelling pubmed-32346162012-01-23 Promoting Effects of Streptozotocin-induced Diabetes on Induction of Hepatic Preneoplastic Lesions by Diethylnitrosamine in Rats Ichikawa, Kazuhito Tagawa, Yoshiaki Kawai, Masaomi Asamoto, Makoto Shirai, Tomoyuki J Toxicol Pathol Original The effects of streptozotocin (STZ)-induced diabetes on induction of hepatic preneoplastic lesions by diethylnitrosamine (DEN) were investigated in male Fischer rats. A single dose of STZ was injected intravenously either 2 weeks before or after initiation with DEN. The blood glucose levels were significantly elevated from 1 week after STZ-injection until autopsy. The numbers of GST-P positive foci at 1 week after DEN administration in the STZ-injected rats were similar to those in the non-diabetic rats. In contrast, both the numbers and areas of GST-P positive foci > 2 mm in diameter 8 weeks after DEN administration were increased significantly in the rats treated with STZ after DEN exposure compared with the non-diabetic control rats. The results suggest that hepatic preneoplastic lesions initiated with DEN are promoted by STZ treatment-inducing diabetes. The Japanese Society of Toxicologic Pathology 2010-09 2010-10-05 /pmc/articles/PMC3234616/ /pubmed/22272023 http://dx.doi.org/10.1293/tox.23.125 Text en 2010 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Original
Ichikawa, Kazuhito
Tagawa, Yoshiaki
Kawai, Masaomi
Asamoto, Makoto
Shirai, Tomoyuki
Promoting Effects of Streptozotocin-induced Diabetes on Induction of Hepatic Preneoplastic Lesions by Diethylnitrosamine in Rats
title Promoting Effects of Streptozotocin-induced Diabetes on Induction of Hepatic Preneoplastic Lesions by Diethylnitrosamine in Rats
title_full Promoting Effects of Streptozotocin-induced Diabetes on Induction of Hepatic Preneoplastic Lesions by Diethylnitrosamine in Rats
title_fullStr Promoting Effects of Streptozotocin-induced Diabetes on Induction of Hepatic Preneoplastic Lesions by Diethylnitrosamine in Rats
title_full_unstemmed Promoting Effects of Streptozotocin-induced Diabetes on Induction of Hepatic Preneoplastic Lesions by Diethylnitrosamine in Rats
title_short Promoting Effects of Streptozotocin-induced Diabetes on Induction of Hepatic Preneoplastic Lesions by Diethylnitrosamine in Rats
title_sort promoting effects of streptozotocin-induced diabetes on induction of hepatic preneoplastic lesions by diethylnitrosamine in rats
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234616/
https://www.ncbi.nlm.nih.gov/pubmed/22272023
http://dx.doi.org/10.1293/tox.23.125
work_keys_str_mv AT ichikawakazuhito promotingeffectsofstreptozotocininduceddiabetesoninductionofhepaticpreneoplasticlesionsbydiethylnitrosamineinrats
AT tagawayoshiaki promotingeffectsofstreptozotocininduceddiabetesoninductionofhepaticpreneoplasticlesionsbydiethylnitrosamineinrats
AT kawaimasaomi promotingeffectsofstreptozotocininduceddiabetesoninductionofhepaticpreneoplasticlesionsbydiethylnitrosamineinrats
AT asamotomakoto promotingeffectsofstreptozotocininduceddiabetesoninductionofhepaticpreneoplasticlesionsbydiethylnitrosamineinrats
AT shiraitomoyuki promotingeffectsofstreptozotocininduceddiabetesoninductionofhepaticpreneoplasticlesionsbydiethylnitrosamineinrats

Ejemplares similares