Evaluation of Bone Toxicity in Various Bones of Aged Rats

The aim of the present study was to provide a method for evaluating bone toxicity induced by drugs in various bones in aged rats. Male Crl:CD (SD) rats at 46 weeks of age were administered 15 mg/m(2) body surface area of doxorubicin, which effects the growth plate in weanling rats, weekly for 9 week...

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Autores principales: Noguchi, Chihiro, Miyata, Hiroto, Sato, Yasushi, Iwaki, Yoshinobu, Okuyama, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Toxicologic Pathology 2011
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234621/
https://www.ncbi.nlm.nih.gov/pubmed/22272043
http://dx.doi.org/10.1293/tox.24.41
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author Noguchi, Chihiro
Miyata, Hiroto
Sato, Yasushi
Iwaki, Yoshinobu
Okuyama, Shigeru
author_facet Noguchi, Chihiro
Miyata, Hiroto
Sato, Yasushi
Iwaki, Yoshinobu
Okuyama, Shigeru
author_sort Noguchi, Chihiro
collection PubMed
description The aim of the present study was to provide a method for evaluating bone toxicity induced by drugs in various bones in aged rats. Male Crl:CD (SD) rats at 46 weeks of age were administered 15 mg/m(2) body surface area of doxorubicin, which effects the growth plate in weanling rats, weekly for 9 weeks by intravenous injection, and the femur, sternum, humerus and tibia were examined histopathologically. In the doxorubicin-treated group, thinning of the growth plate was remarkably observed in the proximal tibia and humerus; however, these changes were not observed in other regions. In addition, the osteoclast number per bone perimeter in the proximal tibia was significantly higher than others in control aged rat. Thus, recognizing the various histological reactions related to the time of epiphyseal closure is important for evaluating bone toxicity in aged rats.
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spelling pubmed-32346212012-01-23 Evaluation of Bone Toxicity in Various Bones of Aged Rats Noguchi, Chihiro Miyata, Hiroto Sato, Yasushi Iwaki, Yoshinobu Okuyama, Shigeru J Toxicol Pathol Original The aim of the present study was to provide a method for evaluating bone toxicity induced by drugs in various bones in aged rats. Male Crl:CD (SD) rats at 46 weeks of age were administered 15 mg/m(2) body surface area of doxorubicin, which effects the growth plate in weanling rats, weekly for 9 weeks by intravenous injection, and the femur, sternum, humerus and tibia were examined histopathologically. In the doxorubicin-treated group, thinning of the growth plate was remarkably observed in the proximal tibia and humerus; however, these changes were not observed in other regions. In addition, the osteoclast number per bone perimeter in the proximal tibia was significantly higher than others in control aged rat. Thus, recognizing the various histological reactions related to the time of epiphyseal closure is important for evaluating bone toxicity in aged rats. The Japanese Society of Toxicologic Pathology 2011-03-31 2011-03 /pmc/articles/PMC3234621/ /pubmed/22272043 http://dx.doi.org/10.1293/tox.24.41 Text en ©2011 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Original
Noguchi, Chihiro
Miyata, Hiroto
Sato, Yasushi
Iwaki, Yoshinobu
Okuyama, Shigeru
Evaluation of Bone Toxicity in Various Bones of Aged Rats
title Evaluation of Bone Toxicity in Various Bones of Aged Rats
title_full Evaluation of Bone Toxicity in Various Bones of Aged Rats
title_fullStr Evaluation of Bone Toxicity in Various Bones of Aged Rats
title_full_unstemmed Evaluation of Bone Toxicity in Various Bones of Aged Rats
title_short Evaluation of Bone Toxicity in Various Bones of Aged Rats
title_sort evaluation of bone toxicity in various bones of aged rats
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234621/
https://www.ncbi.nlm.nih.gov/pubmed/22272043
http://dx.doi.org/10.1293/tox.24.41
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AT iwakiyoshinobu evaluationofbonetoxicityinvariousbonesofagedrats
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