Enhanced Urinary Bladder, Liver and Colon Carcinogenesis in Zucker Diabetic Fatty Rats in a Multiorgan Carcinogenesis Bioassay: Evidence for Mechanisms Involving Activation of PI3K Signaling and Impairment of p53 on Urinary Bladder Carcinogenesis

In the present study, modifying effects of diabetes on carcinogenesis induced in type 2 diabetes mellitus model Zucker diabetic fatty (ZDF) rats were investigated using a multiorgan carcinogenesis bioassay. Our re sults demonstrated enhancement of urinary bladder, colon and liver carcinogenesis in Z...

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Detalles Bibliográficos
Autores principales: Ishii, Naomi, Wei, Min, Kakehashi, Anna, Doi, Kenichiro, Yamano, Shotaro, Inaba, Masaaki, Wanibuchi, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Toxicologic Pathology 2011
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234622/
https://www.ncbi.nlm.nih.gov/pubmed/22272041
http://dx.doi.org/10.1293/tox.24.25

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