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Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat

Carcinosarcomas are rare tumors in humans as well as rats and most commonly occur in the uterus. Recently, we observed a case of incidental carcinosarcoma of the uterus in a female Wistar Hannover GALAS [BrlHan:WIST@ Jcl (GALAS)] rat at 2 years of age. Histopathologically, the tumor was characterize...

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Autores principales: Takami, Shigeaki, Ogawa, Kumiko, Umemura, Takashi, Hibi, Daisuke, Ishii, Yuji, Okamura, Toshiya, Tasaki, Masako, Inoue, Tomoki, Suzuki, Yuta, Jin, Meilan, Cho, Young-Man, Nishikawa, Akiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Toxicologic Pathology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234623/
https://www.ncbi.nlm.nih.gov/pubmed/22272045
http://dx.doi.org/10.1293/tox.24.63
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author Takami, Shigeaki
Ogawa, Kumiko
Umemura, Takashi
Hibi, Daisuke
Ishii, Yuji
Okamura, Toshiya
Tasaki, Masako
Inoue, Tomoki
Suzuki, Yuta
Jin, Meilan
Cho, Young-Man
Nishikawa, Akiyoshi
author_facet Takami, Shigeaki
Ogawa, Kumiko
Umemura, Takashi
Hibi, Daisuke
Ishii, Yuji
Okamura, Toshiya
Tasaki, Masako
Inoue, Tomoki
Suzuki, Yuta
Jin, Meilan
Cho, Young-Man
Nishikawa, Akiyoshi
author_sort Takami, Shigeaki
collection PubMed
description Carcinosarcomas are rare tumors in humans as well as rats and most commonly occur in the uterus. Recently, we observed a case of incidental carcinosarcoma of the uterus in a female Wistar Hannover GALAS [BrlHan:WIST@ Jcl (GALAS)] rat at 2 years of age. Histopathologically, the tumor was characterized by an admixture of malignant epithelial and nonepithelial elements. The carcinomatous components represented a type of endometrial carcinoma, consisting of glandular and solid proliferation of large-sized tumor cells. Prominent mitoses and tumor cell invasion were observed. The sarcomatous components were characterized by multifocal proliferation of severe atypical cells with cartilage matrix and were diagnosed as chondrosarcoma. Transitions between carcinomatous and sarcomatous components were observed, and many tumor cells in the solid lesion showed immunohistochemical reactivity with both cytokeratin and vimentin. Based on these findings, this tumor was diagnosed as a uterine carcinosarcoma. This is the first report of uterine carcinosarcoma in Wistar Hannover GALAS [BrlHan:WIST@Jcl (GALAS)] rats.
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spelling pubmed-32346232012-01-23 Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat Takami, Shigeaki Ogawa, Kumiko Umemura, Takashi Hibi, Daisuke Ishii, Yuji Okamura, Toshiya Tasaki, Masako Inoue, Tomoki Suzuki, Yuta Jin, Meilan Cho, Young-Man Nishikawa, Akiyoshi J Toxicol Pathol Case Report Carcinosarcomas are rare tumors in humans as well as rats and most commonly occur in the uterus. Recently, we observed a case of incidental carcinosarcoma of the uterus in a female Wistar Hannover GALAS [BrlHan:WIST@ Jcl (GALAS)] rat at 2 years of age. Histopathologically, the tumor was characterized by an admixture of malignant epithelial and nonepithelial elements. The carcinomatous components represented a type of endometrial carcinoma, consisting of glandular and solid proliferation of large-sized tumor cells. Prominent mitoses and tumor cell invasion were observed. The sarcomatous components were characterized by multifocal proliferation of severe atypical cells with cartilage matrix and were diagnosed as chondrosarcoma. Transitions between carcinomatous and sarcomatous components were observed, and many tumor cells in the solid lesion showed immunohistochemical reactivity with both cytokeratin and vimentin. Based on these findings, this tumor was diagnosed as a uterine carcinosarcoma. This is the first report of uterine carcinosarcoma in Wistar Hannover GALAS [BrlHan:WIST@Jcl (GALAS)] rats. The Japanese Society of Toxicologic Pathology 2011-03-31 2011-03 /pmc/articles/PMC3234623/ /pubmed/22272045 http://dx.doi.org/10.1293/tox.24.63 Text en ©2011 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Case Report
Takami, Shigeaki
Ogawa, Kumiko
Umemura, Takashi
Hibi, Daisuke
Ishii, Yuji
Okamura, Toshiya
Tasaki, Masako
Inoue, Tomoki
Suzuki, Yuta
Jin, Meilan
Cho, Young-Man
Nishikawa, Akiyoshi
Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
title Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
title_full Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
title_fullStr Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
title_full_unstemmed Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
title_short Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
title_sort uterine carcinosarcoma in a 2-year-old female wistar hannover galas rat
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234623/
https://www.ncbi.nlm.nih.gov/pubmed/22272045
http://dx.doi.org/10.1293/tox.24.63
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