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Successful Drug Development Despite Adverse Preclinical Findings Part 2: Examples
To illustrate the process of addressing adverse preclinical findings (APFs) as outlined in the first part of this review, a number of cases with unexpected APF in toxicity studies with drug candidates is discussed in this second part. The emphasis is on risk characterization, especially regarding th...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Japanese Society of Toxicologic Pathology
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234630/ https://www.ncbi.nlm.nih.gov/pubmed/22272032 http://dx.doi.org/10.1293/tox.23.213 |