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Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats

Equisetum arvense, commonly known as the field horsetail, has potential as a new functional food ingredient. However, little information is available on its side effects, and the general toxicity of Equisetum arvense has yet to be examined in detail. In the present study, we evaluated the influence...

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Autores principales: Tago, Yoshiyuki, Wei, Min, Ishii, Naomi, Kakehashi, Anna, Wanibuchi, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Toxicologic Pathology 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234635/
https://www.ncbi.nlm.nih.gov/pubmed/22272034
http://dx.doi.org/10.1293/tox.23.245
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author Tago, Yoshiyuki
Wei, Min
Ishii, Naomi
Kakehashi, Anna
Wanibuchi, Hideki
author_facet Tago, Yoshiyuki
Wei, Min
Ishii, Naomi
Kakehashi, Anna
Wanibuchi, Hideki
author_sort Tago, Yoshiyuki
collection PubMed
description Equisetum arvense, commonly known as the field horsetail, has potential as a new functional food ingredient. However, little information is available on its side effects, and the general toxicity of Equisetum arvense has yet to be examined in detail. In the present study, we evaluated the influence of administration in diet at doses of 0, 0.3, 1 and 3% for 13 weeks in male and female F344 rats. No toxicity was detected with reference to clinical signs, body weight, urinalysis, hematology and serum biochemistry data and organ weights. Microscopic examination revealed no histopathological lesions associated with treatment. In conclusion, the no-observed-adverse-effect level (NOAEL) for Equisetum arvense was determined to be greater than 3% in both sexes of F344 rat (males and females: >1.79 g/kg BW/day and >1.85 g/kg BW/day, respectively) under the conditions of the present study.
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spelling pubmed-32346352012-01-23 Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats Tago, Yoshiyuki Wei, Min Ishii, Naomi Kakehashi, Anna Wanibuchi, Hideki J Toxicol Pathol Original Equisetum arvense, commonly known as the field horsetail, has potential as a new functional food ingredient. However, little information is available on its side effects, and the general toxicity of Equisetum arvense has yet to be examined in detail. In the present study, we evaluated the influence of administration in diet at doses of 0, 0.3, 1 and 3% for 13 weeks in male and female F344 rats. No toxicity was detected with reference to clinical signs, body weight, urinalysis, hematology and serum biochemistry data and organ weights. Microscopic examination revealed no histopathological lesions associated with treatment. In conclusion, the no-observed-adverse-effect level (NOAEL) for Equisetum arvense was determined to be greater than 3% in both sexes of F344 rat (males and females: >1.79 g/kg BW/day and >1.85 g/kg BW/day, respectively) under the conditions of the present study. The Japanese Society of Toxicologic Pathology 2010-12 2010-12-16 /pmc/articles/PMC3234635/ /pubmed/22272034 http://dx.doi.org/10.1293/tox.23.245 Text en ©2010 The Japanese Society of Toxicologic Pathology
spellingShingle Original
Tago, Yoshiyuki
Wei, Min
Ishii, Naomi
Kakehashi, Anna
Wanibuchi, Hideki
Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats
title Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats
title_full Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats
title_fullStr Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats
title_full_unstemmed Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats
title_short Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats
title_sort evaluation of the subchronic toxicity of dietary administered equisetum arvense in f344 rats
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234635/
https://www.ncbi.nlm.nih.gov/pubmed/22272034
http://dx.doi.org/10.1293/tox.23.245
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