Spontaneous Fibrosarcoma with Pleomorphic Appearance in an Aged Brown Norway Rat

An 18-month-old male Brown Norway (BN) rat showed a grayish-white subcutaneous mass in the right cheek. Histologically, the mass was composed of highly pleomorphic cells producing collagen. Immunohistochemical analysis showed that the tumor cells were strongly positive for vimentin and partially pos...

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Detalles Bibliográficos
Autores principales: Tochitani, Tomoaki, Toyosawa, Kaoru, Matsumoto, Izumi, Kouchi, Mami, Michimae, Yoshiko, Koujitani, Takatoshi, Funabashi, Hitoshi, Seki, Takaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Toxicologic Pathology 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234636/
https://www.ncbi.nlm.nih.gov/pubmed/22272036
http://dx.doi.org/10.1293/tox.23.261
Descripción
Sumario:An 18-month-old male Brown Norway (BN) rat showed a grayish-white subcutaneous mass in the right cheek. Histologically, the mass was composed of highly pleomorphic cells producing collagen. Immunohistochemical analysis showed that the tumor cells were strongly positive for vimentin and partially positive for Ki-67; however, they were negative for ED-1, ED-2, S-100, cytokeratin, desmin and myoglobin. Ultrastructurally, the cytoplasms of the tumor cells contained well-developed rough endoplasmic reticulum. Thus, the tumor had no characteristic feature other than collagen production and was diagnosed as a fibrosarcoma.

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