Spontaneous Fibrosarcoma with Pleomorphic Appearance in an Aged Brown Norway Rat

An 18-month-old male Brown Norway (BN) rat showed a grayish-white subcutaneous mass in the right cheek. Histologically, the mass was composed of highly pleomorphic cells producing collagen. Immunohistochemical analysis showed that the tumor cells were strongly positive for vimentin and partially pos...

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Autores principales: Tochitani, Tomoaki, Toyosawa, Kaoru, Matsumoto, Izumi, Kouchi, Mami, Michimae, Yoshiko, Koujitani, Takatoshi, Funabashi, Hitoshi, Seki, Takaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Toxicologic Pathology 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234636/
https://www.ncbi.nlm.nih.gov/pubmed/22272036
http://dx.doi.org/10.1293/tox.23.261
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author Tochitani, Tomoaki
Toyosawa, Kaoru
Matsumoto, Izumi
Kouchi, Mami
Michimae, Yoshiko
Koujitani, Takatoshi
Funabashi, Hitoshi
Seki, Takaki
author_facet Tochitani, Tomoaki
Toyosawa, Kaoru
Matsumoto, Izumi
Kouchi, Mami
Michimae, Yoshiko
Koujitani, Takatoshi
Funabashi, Hitoshi
Seki, Takaki
author_sort Tochitani, Tomoaki
collection PubMed
description An 18-month-old male Brown Norway (BN) rat showed a grayish-white subcutaneous mass in the right cheek. Histologically, the mass was composed of highly pleomorphic cells producing collagen. Immunohistochemical analysis showed that the tumor cells were strongly positive for vimentin and partially positive for Ki-67; however, they were negative for ED-1, ED-2, S-100, cytokeratin, desmin and myoglobin. Ultrastructurally, the cytoplasms of the tumor cells contained well-developed rough endoplasmic reticulum. Thus, the tumor had no characteristic feature other than collagen production and was diagnosed as a fibrosarcoma.
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spelling pubmed-32346362012-01-23 Spontaneous Fibrosarcoma with Pleomorphic Appearance in an Aged Brown Norway Rat Tochitani, Tomoaki Toyosawa, Kaoru Matsumoto, Izumi Kouchi, Mami Michimae, Yoshiko Koujitani, Takatoshi Funabashi, Hitoshi Seki, Takaki J Toxicol Pathol Case Report An 18-month-old male Brown Norway (BN) rat showed a grayish-white subcutaneous mass in the right cheek. Histologically, the mass was composed of highly pleomorphic cells producing collagen. Immunohistochemical analysis showed that the tumor cells were strongly positive for vimentin and partially positive for Ki-67; however, they were negative for ED-1, ED-2, S-100, cytokeratin, desmin and myoglobin. Ultrastructurally, the cytoplasms of the tumor cells contained well-developed rough endoplasmic reticulum. Thus, the tumor had no characteristic feature other than collagen production and was diagnosed as a fibrosarcoma. The Japanese Society of Toxicologic Pathology 2010-12 2010-12-16 /pmc/articles/PMC3234636/ /pubmed/22272036 http://dx.doi.org/10.1293/tox.23.261 Text en ©2010 The Japanese Society of Toxicologic Pathology
spellingShingle Case Report
Tochitani, Tomoaki
Toyosawa, Kaoru
Matsumoto, Izumi
Kouchi, Mami
Michimae, Yoshiko
Koujitani, Takatoshi
Funabashi, Hitoshi
Seki, Takaki
Spontaneous Fibrosarcoma with Pleomorphic Appearance in an Aged Brown Norway Rat
title Spontaneous Fibrosarcoma with Pleomorphic Appearance in an Aged Brown Norway Rat
title_full Spontaneous Fibrosarcoma with Pleomorphic Appearance in an Aged Brown Norway Rat
title_fullStr Spontaneous Fibrosarcoma with Pleomorphic Appearance in an Aged Brown Norway Rat
title_full_unstemmed Spontaneous Fibrosarcoma with Pleomorphic Appearance in an Aged Brown Norway Rat
title_short Spontaneous Fibrosarcoma with Pleomorphic Appearance in an Aged Brown Norway Rat
title_sort spontaneous fibrosarcoma with pleomorphic appearance in an aged brown norway rat
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234636/
https://www.ncbi.nlm.nih.gov/pubmed/22272036
http://dx.doi.org/10.1293/tox.23.261
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