Thirteen-week Intravenous Toxicity Study of a Novel Humanized Anti-Human Death Receptor 5 Monoclonal Antibody, CS-1008, in Cynomolgus Monkeys

CS-1008, a humanized monoclonal antibody that is agonistic to human death receptor 5, was intravenously administered to cynomolgus monkeys twice a week for 13 weeks at 3 different dose levels (5, 15 and 42 mg/kg) in order to evaluate its potential toxicity. A control group received phosphate buffere...

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Detalles Bibliográficos
Autores principales: Kimotsuki, Tomofumi, Tanaka, Kohji, Sugiura, Tomomi, Koyama, Kumiko, Nakamura, Takahiro, Kamimura, Yasuhiro, Takasaki, Wataru, Manabe, Sunao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Toxicologic Pathology 2010
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234651/
https://www.ncbi.nlm.nih.gov/pubmed/22272006
http://dx.doi.org/10.1293/tox.23.11

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