γ-Secretase and Presenilin Mediate Cleavage and Phosphorylation of Vascular Endothelial Growth Factor Receptor-1

We have reported previously that pigment epithelium-derived factor (PEDF) can, via γ-secretase-mediated events, inhibit VEGF-induced angiogenesis in microvascular endothelial cells by both (a) cleavage and intracellular translocation of a C-terminal fragment of VEGF receptor-1 (VEGFR1) and (b) inhib...

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Detalles Bibliográficos
Autores principales: Cai, Jun, Chen, Zhijuan, Ruan, Qing, Han, Song, Liu, Li, Qi, Xiaoping, Boye, Sanford L., Hauswirth, William W., Grant, Maria B., Boulton, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234916/
https://www.ncbi.nlm.nih.gov/pubmed/22016384
http://dx.doi.org/10.1074/jbc.M111.296590

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