Dantrolene is neuroprotective in Huntington's disease transgenic mouse model

BACKGROUND: Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine expansion in the Huntingtin protein which results in the selective degeneration of striatal medium spiny neurons (MSNs). Our group has previously demonstrated that calcium (Ca(2+)) signal...

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Detalles Bibliográficos
Autores principales: Chen, Xi, Wu, Jun, Lvovskaya, Svetlana, Herndon, Emily, Supnet, Charlene, Bezprozvanny, Ilya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235068/
https://www.ncbi.nlm.nih.gov/pubmed/22118545
http://dx.doi.org/10.1186/1750-1326-6-81

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