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Different Phenotypic Consequences of Simultaneous Versus Stepwise Apc Loss

APC is considered a gatekeeper for colorectal cancer (CRC). Cells with heterozygous APC mutations have altered expression profiles suggesting that the first APC hit may help set the stage for subsequent transformation. Therefore, we measured transformation efficiency following what we have designate...

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Detalles Bibliográficos
Autores principales:	Fischer, Jared M, Miller, Ashleigh J, Shibata, Darryl, Liskay, R Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235266/ https://www.ncbi.nlm.nih.gov/pubmed/21892206 http://dx.doi.org/10.1038/onc.2011.385

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