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The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma

Tumor microenvironment is composed of tumor cells, fibroblasts, and infiltrating immune cells, which all work together and create an inflammatory environment favoring tumor progression. The present study aimed to investigate the role of the desmoplastic stroma in pancreatic ductal adenocarcinoma (PD...

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Autores principales: Tjomsland, Vegard, Niklasson, Lina, Sandström, Per, Borch, Kurt, Druid, Henrik, Bratthäll, Charlotte, Messmer, Davorka, Larsson, Marie, Spångeus, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235447/
https://www.ncbi.nlm.nih.gov/pubmed/22190968
http://dx.doi.org/10.1155/2011/212810
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author Tjomsland, Vegard
Niklasson, Lina
Sandström, Per
Borch, Kurt
Druid, Henrik
Bratthäll, Charlotte
Messmer, Davorka
Larsson, Marie
Spångeus, Anna
author_facet Tjomsland, Vegard
Niklasson, Lina
Sandström, Per
Borch, Kurt
Druid, Henrik
Bratthäll, Charlotte
Messmer, Davorka
Larsson, Marie
Spångeus, Anna
author_sort Tjomsland, Vegard
collection PubMed
description Tumor microenvironment is composed of tumor cells, fibroblasts, and infiltrating immune cells, which all work together and create an inflammatory environment favoring tumor progression. The present study aimed to investigate the role of the desmoplastic stroma in pancreatic ductal adenocarcinoma (PDAC) regarding expression of inflammatory factors and infiltration of immune cells and their impact on the clinical outcome. The PDAC tissues examined expressed significantly increased levels of immunomodulatory and chemotactic factors (IL-6, TGFβ, IDO, COX-2, CCL2, and CCL20) and immune cell-specific markers corresponding to macrophages, myeloid, and plasmacytoid dendritic cells (DCs) as compared to controls. Furthermore, short-time survivors had the lowest levels of DC markers. Immunostainings indicated that the different immune cells and inflammatory factors are mainly localized to the desmoplastic stroma. Therapies modulating the inflammatory tumor microenvironment to promote the attraction of DCs and differentiation of monocytes into functional DCs might improve the survival of PDAC patients.
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spelling pubmed-32354472011-12-21 The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma Tjomsland, Vegard Niklasson, Lina Sandström, Per Borch, Kurt Druid, Henrik Bratthäll, Charlotte Messmer, Davorka Larsson, Marie Spångeus, Anna Clin Dev Immunol Clinical Study Tumor microenvironment is composed of tumor cells, fibroblasts, and infiltrating immune cells, which all work together and create an inflammatory environment favoring tumor progression. The present study aimed to investigate the role of the desmoplastic stroma in pancreatic ductal adenocarcinoma (PDAC) regarding expression of inflammatory factors and infiltration of immune cells and their impact on the clinical outcome. The PDAC tissues examined expressed significantly increased levels of immunomodulatory and chemotactic factors (IL-6, TGFβ, IDO, COX-2, CCL2, and CCL20) and immune cell-specific markers corresponding to macrophages, myeloid, and plasmacytoid dendritic cells (DCs) as compared to controls. Furthermore, short-time survivors had the lowest levels of DC markers. Immunostainings indicated that the different immune cells and inflammatory factors are mainly localized to the desmoplastic stroma. Therapies modulating the inflammatory tumor microenvironment to promote the attraction of DCs and differentiation of monocytes into functional DCs might improve the survival of PDAC patients. Hindawi Publishing Corporation 2011 2011-12-06 /pmc/articles/PMC3235447/ /pubmed/22190968 http://dx.doi.org/10.1155/2011/212810 Text en Copyright © 2011 Vegard Tjomsland et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Tjomsland, Vegard
Niklasson, Lina
Sandström, Per
Borch, Kurt
Druid, Henrik
Bratthäll, Charlotte
Messmer, Davorka
Larsson, Marie
Spångeus, Anna
The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma
title The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma
title_full The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma
title_fullStr The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma
title_full_unstemmed The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma
title_short The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma
title_sort desmoplastic stroma plays an essential role in the accumulation and modulation of infiltrated immune cells in pancreatic adenocarcinoma
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235447/
https://www.ncbi.nlm.nih.gov/pubmed/22190968
http://dx.doi.org/10.1155/2011/212810
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